Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 19/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 18/20 | 0.42 |
| ▸ | CASP1 | P29466 | 15/20 | 0.42 |
| ▸ | CASP7 | P55210 | 15/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.42 |
| ▸ | USP2 | O75604 | 11/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 13/20 | 0.41 |
| ▸ | HPGD | P15428 | 12/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18017085 | 0.80 | ALDH1A1 (0.45) | CYP1A2ALDH1A1CASP1CASP7CYP3A4 | |
| SCHEMBL8809371 | 0.74 | ALDH1A1 (0.44) | CYP1A2ALDH1A1CASP1CASP7CYP3A4 | |
| SCHEMBL17977053 | 0.74 | CYP1A2 (0.43) | CYP1A2ALDH1A1CYP3A4CYP2C19TSHR | |
| SCHEMBL18017066 | 0.72 | TGFBR1 (0.41) | CYP1A2ALDH1A1CYP3A4USP2CYP2C19 | |
| SCHEMBL18017067 | 0.69 | GPR119 (0.51) | — | |
| Fumaric Acid SCHEMBL8812798 | 0.67 | HSD17B10 (0.43) | CYP1A2ALDH1A1CASP1CASP7CYP3A4 | |
| Maleic Acid SCHEMBL8812791 | 0.67 | HSD17B10 (0.43) | CYP1A2ALDH1A1CASP1CASP7CYP3A4 | |
| SCHEMBL21564400 | 0.67 | ALDH1A1 (0.53) | CYP1A2ALDH1A1CASP1CASP7CYP3A4 | |
| SCHEMBL8810512 | 0.65 | ALDH1A1 (0.51) | CYP1A2ALDH1A1CASP1CASP7CYP3A4 | |
| SCHEMBL16466061 | 0.65 | PTPN11 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180016263-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2018-01-18 | — | — | US | disclosed |
| US-20180016263-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME LLC | 2018-01-18 | — | — | US | disclosed |
| WO-2016127358-A1 | INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2016-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180016263-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, SLC9A1 | CYP1A2 3242/4885ALDH1A1 1373/4885CASP1 1622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.