Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19121870 | 0.86 | GABRA1 (0.41) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL12889914 | 0.81 | CALM1 (0.42) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL13240539 | 0.80 | THRA (0.43) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL29970124 | 0.78 | GABRA1 (0.37) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL30096973 | 0.78 | PTPN11 (0.47) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL19617651 | 0.78 | GABRA1 (0.37) | CYP1A2CYP2C9CYP2C19MEN1CYP3A4 | |
| SCHEMBL8300246 | 0.77 | ESR1 (0.51) | CYP1A2CYP2C9CYP2C19L3MBTL1ALDH1A1 | |
| SCHEMBL12952630 | 0.77 | ALDH1A1 (0.50) | MEN1KMT2AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14026787 | 0.77 | SMN1; SMN2 (0.41) | CYP1A2CYP2C9CYP2C19MEN1KMT2A | |
| SCHEMBL17485632 | 0.76 | L3MBTL1 (0.46) | CYP1A2CYP2C9CYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701650-B2 | Derivatives of sobetirome | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2017-07-11 | — | — | US | disclosed |
| WO-2016134292-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-08-25 | — | — | WO | disclosed |
| US-20160244418-A1 | DERIVATIVES OF SOBETIROME | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244418-A1 | DERIVATIVES OF SOBETIROME | SLC18A2, SLC6A2, SLC6A4 | CYP1A2 207/4885CYP2C9 404/4885CYP2C19 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.