Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 18/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19618668 | 0.85 | TLR8 (0.47) | TLR8TLR7CA12CA9TRPA1 | |
| SCHEMBL18041439 | 0.85 | TLR8 (0.50) | TLR8TLR7TRPA1 | |
| Hydrochloric Acid SCHEMBL18041408 | 0.84 | TLR8 (0.49) | TLR8TLR7TRPA1 | |
| SCHEMBL28772135 | 0.83 | TLR8 (0.42) | TLR8TLR7 | |
| SCHEMBL28772134 | 0.81 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL19619992 | 0.80 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL18041347 | 0.78 | TLR8 (0.72) | TLR8TLR7 | |
| SCHEMBL22771035 | 0.78 | TLR8 (0.57) | TLR8TLR7 | |
| SCHEMBL24699321 | 0.77 | TLR8 (0.48) | TLR8TLR7 | |
| SCHEMBL1095204 | 0.77 | TLR8 (0.49) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822065-B1 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-11-21 | — | — | US | claimed |
| US-20220305115-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PYRIDOPYRIMIDINE DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-09-29 | — | — | US | disclosed |
| EP-3949969-A2 | BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF | Silverback Therapeutics, Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| EP-3468963-B1 | DIHYDROPYRIMIDINYL BENZAZEPINE CARBOXAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2021-10-27 | — | — | EP | disclosed |
| EP-3468963-B1 | DIHYDROPYRIMIDINYL BENZAZEPINE CARBOXAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2021-10-27 | — | — | EP | disclosed |
| EP-3595668-B1 | BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF | SILVERBACK THERAPEUTICS INC (US) | 2021-07-21 | — | — | EP | disclosed |
| US-11046671-B2 | Dihydropyrimidinyl benzazepine carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2021-06-29 | — | — | US | disclosed |
| US-11046671-B2 | Dihydropyrimidinyl benzazepine carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2021-06-29 | — | — | US | disclosed |
| US-20210154317-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS | ARS Pharmaceuticals, Inc. | 2021-05-27 | — | — | US | disclosed |
| EP-3464245-B1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS WITH TERTIARY AMIDE FUNCTION | HOFFMANN LA ROCHE (CH) | 2020-10-14 | — | — | EP | disclosed |
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-9475775-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475775-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-9475775-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-10-25 | — | — | US | disclosed |
| WO-2016142250-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016142250-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-15 | — | — | WO | disclosed |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | TLR1, TLR4, TLR5 | TLR8 6/4885TLR7 9/4885CA12 3293/4885 |
| US-20160257653-A1 | Benzazepine Dicarboxamide Compounds | TLR1, TLR4, TLR5 | TLR8 6/4885TLR7 9/4885CA12 3293/4885 |
| US-20210154317-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS | HAVCR2, FCGR3B, FCGR1A | TLR8 120/4885TLR7 63/4885CA12 1417/4885 |
| US-20220305115-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PYRIDOPYRIMIDINE DERIVATIVES | HAVCR2, ENTPD5, HMGB3 | TLR8 158/4885TLR7 60/4885CA12 3612/4885 |
| US-11046671-B2 | Dihydropyrimidinyl benzazepine carboxamide compounds | TLR8, TLR1, TLR5 | TLR8 1/4885TLR7 8/4885CA12 4636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.