Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30096678 | 1.00 | HTR2A (0.45) | HTR2ARETSIGMAR1ACP3CHRM1 | |
| SCHEMBL23832807 | 1.00 | HTR2A (0.45) | HTR2ARETSIGMAR1ACP3CHRM1 | |
| SCHEMBL19997052 | 0.81 | HTR2A (0.56) | HTR2ARETSIGMAR1ACP3IDO1 | |
| SCHEMBL25076290 | 0.77 | SIGMAR1 (0.41) | HTR2ARETSIGMAR1ACP3ADRA2B | |
| SCHEMBL16559390 | 0.76 | ALDH1A1 (0.50) | HTR2ASIGMAR1CHRM1DRD2ADRA2B | |
| SCHEMBL25076717 | 0.75 | CHRNA7 (0.36) | HTR2ARETSIGMAR1ACP3IDO1 | |
| SCHEMBL23832773 | 0.75 | HTR2A (0.46) | HTR2ARETSIGMAR1DRD2HTR2C | |
| SCHEMBL25076280 | 0.74 | HTR2A (0.39) | HTR2ARETSIGMAR1IDO1 | |
| SCHEMBL25076414 | 0.74 | SIGMAR1 (0.41) | HTR2ARETSIGMAR1CHRM1DRD2 | |
| SCHEMBL25076342 | 0.74 | HTR2A (0.39) | HTR2ARETSIGMAR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208045-B2 | Aza-pyridone compounds and uses thereof | ALIOS BIOPHARMA, INC. (US) | 2019-02-19 | — | — | US | disclosed |
| US-20160264581-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | Janssen Pharmaceuticals, Inc. | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10208045-B2 | Aza-pyridone compounds and uses thereof | PNPO, ITPA, PDXK | HTR2A 2492/4885RET 2410/4885SIGMAR1 4315/4885 |
| US-20160264581-A1 | AZA-PYRIDONE COMPOUNDS AND USES THEREOF | PNPO, ITPA, PDXK | HTR2A 2492/4885RET 2410/4885SIGMAR1 4315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.