SCHEMBL18045735

SCHEMBL18045735

O=c1oc(=O)c2cc(Oc3ccccc3)c3c4ccccc4oc4ccc1c2c43

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 3/20 0.50
▸ L3MBTL1 Q9Y468 2/20 0.50
▸ RAB9A P51151 2/20 0.50
▸ POLB P06746 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.44
▸ KMT2A Q03164 2/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ ACHE P22303 1/20 0.39
▸ MAOA P21397 5/20 0.39
▸ KCNA3 P22001 1/20 0.39
▸ ALDH1A1 P00352 3/20 0.38
▸ GLA P06280 2/20 0.38
▸ MAPT P10636 2/20 0.38
▸ PPARG P37231 1/20 0.38
▸ NCOA2 Q15596 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ RXFP1 Q9HBX9 1/20 0.38
▸ ACSL1 P33121 2/20 0.37
▸ ACSL6 Q9UKU0 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18045731 0.87 L3MBTL1 (0.44) NPC1L3MBTL1RAB9APOLBTDP1
SCHEMBL17439419 0.75 RAB9A (0.39) NPC1L3MBTL1RAB9APOLBKMT2A
SCHEMBL16686906 0.75 KMT2A (0.47) NPC1L3MBTL1RAB9APOLBKMT2A
SCHEMBL18045732 0.75 KMT2A (0.47) NPC1L3MBTL1RAB9APOLBKMT2A
SCHEMBL12832441 0.73 TDP1 (0.56) NPC1L3MBTL1RAB9ATDP1KMT2A
SCHEMBL29886854 0.73 TDP1 (0.56) NPC1L3MBTL1RAB9ATDP1KMT2A
SCHEMBL24566597 0.71 GAA (0.50) NPC1L3MBTL1RAB9APOLBMAOA
SCHEMBL29684492 0.71 AHR (0.47) NPC1L3MBTL1RAB9APOLBKMT2A
SCHEMBL24566937 0.71 MEN1 (0.46) NPC1L3MBTL1RAB9APOLBKMT2A
SCHEMBL29031922 0.70 MAOA (0.67) NPC1L3MBTL1RAB9APOLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107074871-B Organic phosphors based on benzimidazol-oxaanthrenoisonone derivatives for LED lighting 飞利浦照明控股有限公司 2020-06-19 — — CN disclosed
US-10329482-B2 Class of organic phosphors based on derivatives of benzimidazoxanthenoisoquinolinone for LED lighting SIGNIFY HOLDING B.V. (NL) 2019-06-25 — — US disclosed
EP-3063249-B1 NEW CLASS OF GREEN/YELLOW EMITTING PHOSPHORS BASED ON DERIVATIVES OF BENZIMIDAZOXANTHENOISOQUINOLINONE FOR LED LIGHTING SIGNIFY HOLDING BV (NL) 2019-04-17 — — EP disclosed
EP-3063249-B1 NEW CLASS OF GREEN/YELLOW EMITTING PHOSPHORS BASED ON DERIVATIVES OF BENZIMIDAZOXANTHENOISOQUINOLINONE FOR LED LIGHTING SIGNIFY HOLDING BV (NL) 2019-04-17 — — EP disclosed
EP-3209747-B1 NEW CLASS OF ORGANIC PHOSPHORS BASED ON DERIVATIVES OF BENZIMIDAZOXANTHENOISOQUINOLINONE FOR LED LIGHTING PHILIPS LIGHTING HOLDING BV (NL) 2018-12-12 — — EP disclosed
US-20180016491-A1 NEW CLASS OF ORGANIC PHOSPHORS BASED ON DERIVATIVES OF BENZIMIDAZOXANTHENOISOQUINOLINONE FOR LED LIGHTING PHILIPS LIGHTING HOLDING B.V. (NL) 2018-01-18 — — US disclosed
US-9676998-B2 Class of green/yellow emitting phosphors based on derivatives of benzimidazoxanthenoisoquinolinone for LED lighting PHILIPS LIGHTING HOLDING B.V. (NL) 2017-06-13 — — US disclosed
US-9676998-B2 Class of green/yellow emitting phosphors based on derivatives of benzimidazoxanthenoisoquinolinone for LED lighting PHILIPS LIGHTING HOLDING B.V. (NL) 2017-06-13 — — US disclosed
US-20160264860-A1 CLASS OF GREEN/YELLOW EMITTING PHOSPHORS BASED ON DERIVATIVES OF BENZIMIDAZOXANTHENOISOQUINOLINONE FOR LED LIGHTING SIGNIFY HOLDING B.V. (NL) 2016-09-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10329482-B2 Class of organic phosphors based on derivatives of benzimidazoxanthenoisoquinolinone for LED lighting PNPO, P2RY4, P2RX4 NPC1 4850/4885L3MBTL1 2664/4885RAB9A 3806/4885
US-20180016491-A1 NEW CLASS OF ORGANIC PHOSPHORS BASED ON DERIVATIVES OF BENZIMIDAZOXANTHENOISOQUINOLINONE FOR LED LIGHTING PNPO, PPOX, PIR NPC1 4836/4885L3MBTL1 2443/4885RAB9A 3323/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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