Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.37 |
| ▸ | MMP8 | P22894 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 5/20 | 0.34 |
| ▸ | BMP1 | P13497 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048549 | 1.00 | MMP2 (0.37) | MMP2MMP9MMP8MMP1BMP1 | |
| SCHEMBL18272890 | 0.86 | ADAM17 (0.40) | MMP2MMP9MMP8MMP1BMP1 | |
| SCHEMBL28195728 | 0.84 | ECE1 (0.40) | ACE | |
| SCHEMBL21289601 | 0.82 | CTSD (0.34) | MMP2MMP9MMP8MMP1 | |
| SCHEMBL25264872 | 0.81 | PDF (0.35) | MMP9MMP8 | |
| SCHEMBL22317363 | 0.78 | KISS1R (0.41) | MMP2MMP9MMP8MMP1BMP1 | |
| SCHEMBL8217798 | 0.78 | CTSD (0.31) | — | |
| SCHEMBL22421642 | 0.78 | MMP1 (0.38) | MMP9MMP1CTSSCTSKSMN1; SMN2 | |
| SCHEMBL29878045 | 0.78 | MMP1 (0.38) | MMP9MMP1CTSSCTSKSMN1; SMN2 | |
| SCHEMBL24337164 | 0.78 | MMP1 (0.38) | MMP9MMP1CTSSCTSKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268038-A1 | ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO FLT3 PROTEINS | Agensys, Inc. (US) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016145099-A1 | ANTIBODY DRUG CONJUGATES (ADC) THAT BIND TO FLT3 PROTEINS | AGENSYS, INC. (US) | 2016-09-15 | — | — | WO | disclosed |