Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18049822 | 0.83 | KDM4E (0.36) | HPGD | |
| SCHEMBL4053314 | 0.79 | TDP1 (0.47) | AKR1B1KEAP1NFE2L2TDP1CYP2C9 | |
| SCHEMBL18049772 | 0.77 | PTGER1 (0.43) | AKR1B1KEAP1NFE2L2TDP1PTGER1 | |
| SCHEMBL7827157 | 0.77 | AKR1B1 (0.67) | AKR1B1TDP1PTGER1PTGER4PTGER3 | |
| SCHEMBL18049789 | 0.76 | HSD17B10 (0.42) | KEAP1NFE2L2TDP1HPGD | |
| SCHEMBL18049807 | 0.72 | GPR35 (0.44) | AKR1B1KEAP1NFE2L2TDP1PTGER1 | |
| SCHEMBL30726783 | 0.72 | GPR35 (0.44) | AKR1B1KEAP1NFE2L2TDP1PTGER1 | |
| SCHEMBL4048685 | 0.70 | LTA4H (0.54) | AKR1B1TDP1PTGER1PTGER4PTGER3 | |
| Biphenyl SCHEMBL11146899 | 0.70 | AKR1B1 (0.57) | AKR1B1TDP1PTGER1PTGER4PTGER3 | |
| SCHEMBL28753686 | 0.69 | TDP1 (0.55) | AKR1B1TDP1PTGS2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268375-B1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2022-06-15 | — | — | EP | disclosed |
| CN-107406459-B | Photochromic thienobenzopyran compounds | 光学转变公司 | 2021-06-08 | — | — | CN | disclosed |
| US-20180051037-A1 | Photochromic Thienochromene Compounds | TRANSITIONS OPTICAL, INC. | 2018-02-22 | — | — | US | disclosed |
| EP-3268375-A1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | Transitions Optical, Inc. (US) | 2018-01-17 | — | — | EP | disclosed |
| CN-107406459-A | Photochromic thiophene and benzopyran compounds | 光学转变公司 | 2017-11-28 | — | — | CN | disclosed |
| WO-2016144324-A1 | PHOTOCHROMIC THIENOCHROMENE COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2016-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180051037-A1 | Photochromic Thienochromene Compounds | CRY1, CRY2, TERT | AKR1B1 658/4885KEAP1 15/4885NFE2L2 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.