Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 12/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18065745 | 0.88 | OPRM1 (0.46) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL10038876 | 0.73 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL158960 | 0.73 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL380587 | 0.72 | OPRM1 (0.72) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2436154 | 0.70 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2435568 | 0.68 | OPRM1 (0.67) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL4765365 | 0.68 | OPRM1 (0.63) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL11871001 | 0.68 | ALDH1A1 (0.42) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL15391670 | 0.67 | OPRM1 (0.66) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2436358 | 0.67 | OPRM1 (0.66) | OPRM1OGFRL1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160271107-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | GRUENENTHAL GMBH (DE) | 2016-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160271107-A1 | Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency | TACR2, OPRK1, OPRD1 | OPRM1 8/4885OGFRL1 307/4885OPRL1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.