SCHEMBL1807706

SCHEMBL1807706

CN(C(=O)c1ccc(F)cc1)c1cccc(C(=O)Cl)c1F

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GRM1 Q13255 6/20 0.40
KMT2A Q03164 1/20 0.39
ALDH1A1 P00352 1/20 0.38
ALOX15 P16050 1/20 0.38
TACR1 P25103 1/20 0.37
RAB9A P51151 1/20 0.36
EGFR P00533 1/20 0.36
ERBB2 P04626 1/20 0.36
GRM5 P41594 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
KDM4E B2RXH2 1/20 0.35
CXCR2 P25025 1/20 0.35
NSD2 O96028 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1803701 0.90 ALDH1A1 (0.42) KMT2AALDH1A1ALOX15RAB9AEGFR
SCHEMBL1804980 0.87 KDM4E (0.45) GRM1KMT2AALDH1A1TACR1RAB9A
SCHEMBL20537201 0.84 ALDH1A1 (0.47) KMT2AALDH1A1RAB9A
SCHEMBL1804359 0.83 CYP1A2 (0.49) KMT2AALDH1A1RAB9ACYP1A2CYP2C19
SCHEMBL27938010 0.82 GPBAR1 (0.44) GRM1KMT2ATACR1CYP1A2CYP2C19
SCHEMBL20536772 0.81 ALDH1A1 (0.46) KMT2AALDH1A1ALOX15
SCHEMBL21367353 0.81 KMT2A (0.43) GRM1KMT2ATACR1RAB9AKDM4E
SCHEMBL123481 0.79 GRM1 (0.41) GRM1KMT2ATACR1RAB9AGRM5
SCHEMBL21965336 0.78 CTNNB1 (0.42)
SCHEMBL1802624 0.78 ACLY (0.43) KMT2AALDH1A1ALOX15RAB9AEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3392236-B1 METHOD FOR PRODUCING AROMATIC AMIDE DERIVATIVE MITSUI CHEMICALS AGRO INC (JP) 2021-06-23 EP disclosed
CN-108368030-B Process for producing aromatic amide derivative 三井化学AGRO株式会社 2020-09-18 CN disclosed
US-10647660-B2 Method of producing aromatic amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2020-05-12 US disclosed
EP-2322502-B1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO INC (JP) 2019-09-18 EP disclosed
US-20180362447-A1 METHOD OF PRODUCING AROMATIC AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2018-12-20 US disclosed
EP-3392236-A1 METHOD FOR PRODUCING AROMATIC AMIDE DERIVATIVE Mitsui Chemicals Agro, Inc. (JP) 2018-10-24 EP disclosed
US-9890110-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2018-02-13 US disclosed
US-9890110-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2018-02-13 US disclosed
US-9890110-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2018-02-13 US disclosed
US-20160297750-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2016-10-13 US disclosed
US-8853440-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2014-10-07 US disclosed
US-8853440-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2014-10-07 US disclosed
US-8853440-B2 Method for producing amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2014-10-07 US disclosed
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2014-10-02 US disclosed
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2014-10-02 US disclosed
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2014-10-02 US disclosed
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-09 US disclosed
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-09 US disclosed
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-06-09 US disclosed
EP-2322502-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE Mitsui Chemicals Agro, Inc. (JP) 2011-05-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296560-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 GRM1 247/4885KMT2A 1316/4885ALDH1A1 2424/4885
US-20160297750-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 GRM1 247/4885KMT2A 1316/4885ALDH1A1 2424/4885
US-20180362447-A1 METHOD OF PRODUCING AROMATIC AMIDE DERIVATIVE HDHD5, NAAA, H1-4 GRM1 4686/4885KMT2A 1774/4885ALDH1A1 461/4885
US-20110137068-A1 METHOD FOR PRODUCING AMIDE DERIVATIVE AFF4, AFF1, AFF2 GRM1 247/4885KMT2A 1316/4885ALDH1A1 2424/4885
US-10647660-B2 Method of producing aromatic amide derivative HDHD5, NAAA, H1-4 GRM1 4686/4885KMT2A 1774/4885ALDH1A1 461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.