Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | FES | P07332 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FER | P16591 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806119 | 0.79 | ALDH1A1 (0.39) | PLK4PDPK1DAPK3DYRK3PRKD3 | |
| SCHEMBL1807315 | 0.78 | ALDH1A1 (0.38) | PLK4PDPK1DAPK3DYRK3PRKD3 | |
| SCHEMBL1805611 | 0.72 | PLK4 (0.38) | PLK4PDPK1DAPK3DYRK3PRKD3 | |
| SCHEMBL12464576 | 0.70 | HCAR2 (0.45) | KDRCSNK2A1HCAR2ALDH1A1LMNA | |
| SCHEMBL4947186 | 0.69 | GPBAR1 (0.43) | CYP3A4CYP2C9CYP2C19DHODHDHFR | |
| SCHEMBL1807759 | 0.69 | TDP2 (0.42) | ALDH1A1HSD17B10SMN1; SMN2IDO1ALOX5 | |
| SCHEMBL25240918 | 0.68 | HCAR2 (0.44) | MAPK1HCAR2ALDH1A1 | |
| SCHEMBL6230832 | 0.68 | PTGER1 (0.44) | CDK1CDK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1804834 | 0.67 | PLK4 (0.40) | PLK4PDPK1DAPK3DYRK3PRKD3 | |
| SCHEMBL6844767 | 0.64 | LMNA (0.43) | PLK4PDPK1DAPK3DYRK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |