SCHEMBL1809197

SCHEMBL1809197

CNc1nc(C(=O)O)cs1

nearest known ligand 0.68

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.68
ACHE P22303 1/20 0.53
POLB P06746 2/20 0.53
ECE1 P42892 1/20 0.50
ALDH1A1 P00352 2/20 0.46
NPC1 O15118 1/20 0.46
GAA P10253 1/20 0.46
RAB9A P51151 1/20 0.46
MEN1 O00255 1/20 0.46
MAPT P10636 1/20 0.46
KMT2A Q03164 1/20 0.46
PLA2G4A P47712 1/20 0.45
KDM1A O60341 3/20 0.42
KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL12080962 0.98 L3MBTL1 (0.66) L3MBTL1ACHEPOLBECE1ALDH1A1
SCHEMBL23615217 0.85 L3MBTL1 (0.64) L3MBTL1ACHEPOLBALDH1A1NPC1
SCHEMBL16450798 0.85 L3MBTL1 (0.50) L3MBTL1ACHEPOLBECE1NPC1
SCHEMBL12514043 0.84 KDM1A (0.58) L3MBTL1POLBECE1NPC1GAA
SCHEMBL18236192 0.82 HPGD (0.54) L3MBTL1POLBECE1NPC1GAA
SCHEMBL16397272 0.82 ACHE (0.54) L3MBTL1ACHEPOLBECE1NPC1
SCHEMBL12852563 0.81 MAOA (0.55) L3MBTL1ACHEECE1NPC1GAA
SCHEMBL758061 0.81 L3MBTL1 (1.00) L3MBTL1POLBNPC1RAB9AMAPT
SCHEMBL17895483 0.80 L3MBTL1 (0.62) L3MBTL1ACHEPOLBALDH1A1NPC1
SCHEMBL15996505 0.79 L3MBTL1 (0.45) L3MBTL1POLBALDH1A1NPC1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4590666-A1 THIAZOLE DERIVATIVES AS TAU AGGREGATION INHIBITORS WisTa Laboratories Ltd. (SG) 2025-07-30 EP disclosed
CN-119894874-A Thiazole derivatives as TAU aggregation inhibitors 维斯塔实验室有限公司 2025-04-25 CN disclosed
CN-119546602-A Pyrrolidone derivatives as inhibitors of nfkb-induced kinase 詹森药业有限公司 2025-02-28 CN disclosed
EP-3885340-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2024-11-27 EP disclosed
WO-2024061658-A1 THIAZOLE DERIVATIVES AS TAU AGGREGATION INHIBITORS WISTA LABORATORIES LTD. (SG) 2024-03-28 WO disclosed
US-20230346951-A1 MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS YALE UNIVERSITY 2023-11-02 US disclosed
CN-116783160-A Libraries of compounds 中外制药株式会社 2023-09-19 CN disclosed
EP-3885340-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2021-09-29 EP disclosed
US-11046713-B2 Androgen receptor modulating compounds ORION CORPORATION (FI) 2021-06-29 US disclosed
EP-3369732-B1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORP (FI) 2021-05-26 EP disclosed
WO-2011051540-A9 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2012-06-21 WO disclosed
US-20110294758-A1 NOVEL ACTIVATORS OF GLUCOKINASE METABASIS THERAPEUTICS, INC. (US) 2011-12-01 US disclosed
WO-2011051540-A1 ANDROGEN RECEPTOR MODULATING COMPOUNDS ORION CORPORATION (FI) 2011-05-05 WO disclosed
WO-2011032050-A2 GYRASE INHIBITORS TRIUS THERAPEUTICS, INC. (US) 2011-03-17 WO disclosed
US-20100166706-A1 HCV NS-3 SERINE PROTEASE INHIBITORS MEDIVIR AB (SE) 2010-07-01 US disclosed
EP-1995241-B1 Inhibitors of ion channels ICAGEN INC (US) 2010-03-17 EP disclosed
US-7671032-B2 HCV NS-3 serine protease inhibitors MEDIVIR AB (SE) 2010-03-02 US disclosed
US-20100003216-A1 HCV NS-3 Serine Protease Inhibitors MEDIVIR AB (SE) 2010-01-07 US disclosed
EP-1995241-A1 Inhibitors of ion channels ICAgen, Incorporated (US) 2008-11-26 EP disclosed
US-20070203072-A1 Hcv Ns-3 Serine Protease Inhibitors MEDIVIR AB (SE) 2007-08-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100003216-A1 HCV NS-3 Serine Protease Inhibitors SPINT2, SF3A3, GTF3C3 L3MBTL1 3099/4885ACHE 2939/4885POLB 3876/4885
US-20100166706-A1 HCV NS-3 SERINE PROTEASE INHIBITORS HPN, CPN1, PRSS1 L3MBTL1 1760/4885ACHE 3428/4885POLB 3342/4885
US-20070203072-A1 Hcv Ns-3 Serine Protease Inhibitors HPN, CPN1, PRSS1 L3MBTL1 1080/4885ACHE 3485/4885POLB 3425/4885
US-20230346951-A1 MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS ASGR1, MSR1, LDLR L3MBTL1 2704/4885ACHE 3720/4885POLB 3511/4885
US-11046713-B2 Androgen receptor modulating compounds AR, NR5A1, SHBG L3MBTL1 4871/4885ACHE 3912/4885POLB 4437/4885
US-20110294758-A1 NOVEL ACTIVATORS OF GLUCOKINASE GCKR, GCK, HK1 L3MBTL1 3980/4885ACHE 2033/4885POLB 3914/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.