Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 20/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.86 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14683874 | 0.91 | SLC6A9 (0.72) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL8231084 | 0.85 | SLC6A9 (0.69) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL1811218 | 0.85 | SLC6A9 (0.69) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL1812692 | 0.85 | SLC6A9 (0.69) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL1813500 | 0.85 | SLC6A9 (0.64) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL1813067 | 0.84 | SLC6A9 (0.68) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL1814600 | 0.84 | SLC6A9 (0.67) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL1809793 | 0.83 | SLC6A9 (0.64) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL8227085 | 0.83 | SLC6A9 (0.64) | SLC6A9KCNH2SLC6A5 | |
| SCHEMBL8230080 | 0.83 | SLC6A9 (0.64) | SLC6A9KCNH2SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951836-B2 | Substituted phenyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | claimed |
| JP-2009541251-A | — | — | 2009-11-26 | — | — | JP | claimed |
| EP-2035371-A2 | SUBSTITUTED PHENYL METHANONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-18 | — | — | EP | claimed |
| US-20070299071-A1 | Substituted phenyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | US | claimed |
| WO-2007147770-A2 | SUBSTITUTED PHENYL METHANONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | claimed |
| US-20140121362-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | MICHIGAN DIAGNOSTICS, LLC (US) | 2014-05-01 | — | — | US | disclosed |
| EP-2035371-B1 | SUBSTITUTED PHENYL METHANONE DERIVATIVES AND THEIR USE AS GLYT1 AND GLYT2 RECEPTOR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |
| US-7951836-B2 | Substituted phenyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951836-B2 | Substituted phenyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-7951836-B2 | Substituted phenyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-05-31 | — | — | US | disclosed |
| EP-2035371-A2 | SUBSTITUTED PHENYL METHANONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-18 | — | — | EP | disclosed |
| US-20070299071-A1 | Substituted phenyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | US | disclosed |
| US-20070299071-A1 | Substituted phenyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | US | disclosed |
| US-20070299071-A1 | Substituted phenyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | US | disclosed |
| WO-2007147770-A2 | SUBSTITUTED PHENYL METHANONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299071-A1 | Substituted phenyl methanone derivatives | CYP11B1, CYP11B2, MC2R | SLC6A9 796/4885KCNH2 666/4885SLC6A5 359/4885 |
| US-20140121362-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, MPO | SLC6A9 2644/4885KCNH2 3869/4885SLC6A5 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.