Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18128747 | 0.74 | APEX1 (0.54) | ALDH1A1HSD17B10LMNAAPEX1PKM | |
| SCHEMBL10870623 | 0.74 | HDAC1 (0.48) | ALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL18128748 | 0.73 | LMNA (0.48) | ALDH1A1HSD17B10LMNAAPEX1NUDT1 | |
| SCHEMBL18128755 | 0.71 | PKM (0.48) | ALDH1A1HSD17B10LMNAAPEX1NUDT1 | |
| Niacinamide SCHEMBL8508206 | 0.68 | F7 (0.54) | ALDH1A1LMNAAPEX1NUDT1 | |
| Niacinamide SCHEMBL6371048 | 0.68 | APEX1 (0.71) | ALDH1A1HSD17B10LMNAAPEX1NUDT1 | |
| SCHEMBL7511254 | 0.67 | GRM5 (0.54) | ALDH1A1LMNAGRM5TSHRL3MBTL1 | |
| SCHEMBL18128744 | 0.67 | PI4KA (0.46) | ALDH1A1HSD17B10LMNAPKMMAP4K4 | |
| Niacinamide SCHEMBL3281893 | 0.67 | ADORA2A (0.58) | ALDH1A1LMNAAPEX1NUDT1PKM | |
| SCHEMBL3427969 | 0.64 | ALDH1A1 (0.70) | ALDH1A1LMNAGRM5TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926340-B2 | NAD analogs and methods of using said NAD analogs in determining ribosylation of proteins with PARP mutants | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-03-27 | — | — | US | disclosed |
| US-20160299141-A1 | NAD ANALOGS AND METHODS OF USING SAID NAD ANALOGS IN DETERMINING RIBOSYLATION OF PROTEINS WITH PARP MUTANTS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160299141-A1 | NAD ANALOGS AND METHODS OF USING SAID NAD ANALOGS IN DETERMINING RIBOSYLATION OF PROTEINS WITH PARP MUTANTS | PARP11, PARP14, PARP15 | ALDH1A1 1282/4885HSD17B10 2767/4885LMNA 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.