SCHEMBL18129456

SCHEMBL18129456

NC(=O)c1cccc2c1C(=O)c1ccccc1S2(=O)=O

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.57
NFE2L2 Q16236 1/20 0.57
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
L3MBTL1 Q9Y468 2/20 0.56
GRK6 P43250 1/20 0.48
CHEK1 O14757 2/20 0.47
GPR3 P46089 1/20 0.46
RAB9A P51151 1/20 0.43
MAOA P21397 2/20 0.43
ALDH1A1 P00352 2/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
BCAT2 O15382 1/20 0.42
PARP1 P09874 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11632005 0.86 L3MBTL1 (0.60) MEN1KMT2AL3MBTL1CHEK1GPR3
SCHEMBL20256169 0.79 KMT2A (0.50) MEN1KMT2AL3MBTL1CHEK1GPR3
SCHEMBL20256467 0.77 ADORA2A (0.56) MEN1KMT2AL3MBTL1CHEK1GPR3
SCHEMBL7121384 0.76 KEAP1 (0.86) KEAP1NFE2L2MEN1KMT2AL3MBTL1
SCHEMBL7829487 0.76 KEAP1 (0.73) KEAP1NFE2L2L3MBTL1GRK6ALDH1A1
SCHEMBL27637350 0.75 KEAP1 (0.83) KEAP1NFE2L2MEN1KMT2AL3MBTL1
SCHEMBL30268664 0.74 KEAP1 (0.70) KEAP1NFE2L2MEN1KMT2AL3MBTL1
SCHEMBL5866501 0.74 KEAP1 (0.69) KEAP1NFE2L2L3MBTL1GRK6ALDH1A1
SCHEMBL28230943 0.73 GPR3 (0.52) MEN1KMT2AL3MBTL1CHEK1GPR3
SCHEMBL28450076 0.73 GPR3 (0.47) MEN1KMT2AL3MBTL1CHEK1GPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10030483-B2 Carbon dioxide and hydrocarbon assisted enhanced oil recovery GENERAL ELECTRIC COMPANY (US) 2018-07-24 US disclosed
US-9777122-B2 Thickening compositions, and related materials and processes GENERAL ELECTRIC COMPANY (US) 2017-10-03 US disclosed
US-20170114269-A1 CARBON DIOXIDE AND HYDROCARBON ASSISTED ENHANCED OIL RECOVERY BAKER HUGHES, A GE COMPANY, LLC 2017-04-27 US disclosed
US-20160297934-A1 THICKENING COMPOSITIONS, AND RELATED MATERIALS AND PROCESSES U.S. DEPARTMENT OF ENERGY 2016-10-13 US disclosed
WO-2016164691-A1 THICKENING COMPOSITIONS, AND RELATED MATERIALS AND PROCESSES GENERAL ELECTRIC COMPANY (US) 2016-10-13 WO disclosed