Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18138249 | 0.90 | CNR2 (0.35) | RORCNPC1ALDH1A1KDM4EPTGDR2 | |
| SCHEMBL18138239 | 0.84 | DRD2 (0.39) | ALDH1A1PTGDR2HDAC3HDAC8NCOR2 | |
| SCHEMBL18138297 | 0.79 | GSK3B (0.33) | NPC1PTGDR2HDAC3HDAC8NCOR2 | |
| SCHEMBL19026780 | 0.71 | RAB9A (0.36) | NPC1SMN1; SMN2RAB9ARECQLCYP17A1 | |
| SCHEMBL28055517 | 0.70 | RAF1 (0.49) | NPC1ALDH1A1PTGDR2SMN1; SMN2RAB9A | |
| SCHEMBL24896677 | 0.69 | L3MBTL1 (0.46) | NPC1ALDH1A1KDM4EHDAC3HDAC8 | |
| SCHEMBL12764246 | 0.69 | NPC1 (0.48) | NPC1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL28988125 | 0.68 | HDAC3 (0.52) | HDAC3HDAC8NCOR2SCDCYP17A1 | |
| SCHEMBL15885557 | 0.68 | NPSR1 (0.54) | NPC1ALDH1A1KDM4EPTGDR2LMNA | |
| SCHEMBL16447788 | 0.67 | PTGDR2 (0.40) | KDM4EPTGDR2HDAC3HDAC8NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164754-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |