Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166633 | 0.84 | RXFP1 (0.56) | RXFP1MAPK1TP53ADORA2BLMNA | |
| SCHEMBL12260309 | 0.77 | ADORA2B (0.56) | RXFP1MAPK1TP53ADORA2BLMNA | |
| SCHEMBL18166562 | 0.76 | RXFP1 (0.53) | RXFP1MAPK1TP53ADORA2BLMNA | |
| SCHEMBL9295439 | 0.75 | ADORA2B (0.70) | RXFP1MAPK1TP53ADORA2BLMNA | |
| SCHEMBL11322930 | 0.74 | CYP1A2 (0.58) | RXFP1MAPK1TP53ADORA2BLMNA | |
| SCHEMBL10151088 | 0.74 | ALDH1A1 (0.65) | RXFP1MAPK1TP53ADORA2BLMNA | |
| SCHEMBL10113976 | 0.74 | LMNA (0.70) | RXFP1MAPK1RAB9ATP53ADORA2B | |
| SCHEMBL683968 | 0.73 | RAB9A (0.61) | RXFP1MAPK1RAB9AADORA2BLMNA | |
| SCHEMBL17744968 | 0.73 | RXFP1 (0.75) | RXFP1MAPK1TP53ADORA2BLMNA | |
| SCHEMBL3826453 | 0.73 | TRPA1 (0.77) | RXFP1TP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663295-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | ELI LILLY AND CO. (US) | 2020-06-10 | — | — | EP | disclosed |
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2170309-B1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | HYDRA BIOSCIENCES INC (US) | 2016-10-26 | — | — | EP | disclosed |