Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | GLB1 | P16278 | 1/20 | 0.44 |
| ▸ | CTRC | Q99895 | 1/20 | 0.44 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | TYMS | P04818 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472516 | 0.86 | THRB (0.44) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL154596 | 0.85 | MEN1 (0.40) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL202598 | 0.85 | ALDH1A1 (0.48) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL204164 | 0.85 | ALDH1A1 (0.48) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL1468956 | 0.81 | ALDH1A1 (0.40) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL347626 | 0.80 | THRB (0.50) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL498286 | 0.79 | MEN1 (0.61) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL29486978 | 0.79 | MEN1 (0.61) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL4843133 | 0.79 | RECQL (0.65) | ALDH1A1THRBRECQLTDP1MEN1 | |
| SCHEMBL6823049 | 0.78 | RECQL (0.43) | ALDH1A1THRBRECQLTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3286224-A1 | ISOLATION, DETECTION, DIAGNOSIS AND/OR CHARACTERIZATION OF CIRCULATING TROP-2-POSITIVE CANCER CELLS | Immunomedics, Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| WO-2016172427-A1 | ISOLATION, DETECTION, DIAGNOSIS AND/OR CHARACTERIZATION OF CIRCULATING TROP-2-POSITIVE CANCER CELLS | IMMUNOMEDICS, INC. (US) | 2016-10-27 | — | — | WO | disclosed |