SCHEMBL498286

SCHEMBL498286

O=C1OC2(c3ccccc31)c1cc(Cl)c(O)c(Cl)c1Oc1c2cc(Cl)c(O)c1Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.61
KMT2A Q03164 5/20 0.61
TDP1 Q9NUW8 4/20 0.61
RECQL P46063 2/20 0.61
BLM P54132 2/20 0.61
ACE2 Q9BYF1 2/20 0.61
PRMT1 Q99873 2/20 0.61
L3MBTL1 Q9Y468 2/20 0.61
USP2 O75604 2/20 0.61
THRB P10828 1/20 0.61
CDK2 P24941 1/20 0.61
CHAT P28329 1/20 0.61
BLVRB P30043 1/20 0.61
RXFP1 Q9HBX9 1/20 0.61
GNG2 P59768 1/20 0.59
GNB1 P62873 1/20 0.59
MAPT P10636 6/20 0.52
FTO Q9C0B1 2/20 0.52
CYP2C19 P33261 2/20 0.52
HTT P42858 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29486978 1.00 MEN1 (0.61) MEN1KMT2ATDP1RECQLBLM
SCHEMBL3624632 0.93 GNG2 (0.65) MEN1KMT2ATDP1RECQLBLM
SCHEMBL28626002 0.88 FTO (0.70) MEN1KMT2ATDP1RECQLBLM
SCHEMBL5886188 0.87 MEN1 (0.58) MEN1KMT2ATDP1RECQLBLM
SCHEMBL31105807 0.84 MEN1 (0.55) MEN1KMT2ATDP1RECQLBLM
SCHEMBL122505 0.84 MEN1 (0.55) MEN1KMT2ATDP1RECQLBLM
SCHEMBL203192 0.83 GNG2 (0.43) MEN1KMT2ATDP1RECQLBLM
SCHEMBL6823049 0.83 RECQL (0.43) MEN1KMT2ATDP1RECQLBLM
SCHEMBL498536 0.81 GNG2 (0.74) MEN1KMT2ATDP1RECQLBLM
SCHEMBL29740272 0.81 GNG2 (0.74) MEN1KMT2ATDP1RECQLBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 315 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260132218-A1 FULLY HUMAN MONOCLONAL ANTIBODIES AGAINST HUMAN HER-2 A & G PHARMACEUTICAL INC (US) 2026-05-14 US claimed
US-20250154237-A1 FULLY HUMAN MONOCLONAL ANTIBODIES AGAINST HUMAN PROGRANULIN A & G PHARMACEUTICAL, INC. 2025-05-15 US claimed
EP-4524568-A2 METHODS FOR DETECTION OF RARE SUBPOPULATIONS OF CELLS AND HIGHLY PURIFIED COMPOSITIONS OF CELLS Astellas Institute for Regenerative Medicine (US) 2025-03-19 EP claimed
EP-4482861-A2 FULLY HUMAN MONOCLONAL ANTIBODIES AGAINST HUMAN PROGRANULIN A & G Pharmaceutical, Inc. (US) 2025-01-01 EP claimed
EP-3875599-B1 METHODS FOR DETECTION OF RARE SUBPOPULATIONS OF CELLS AND HIGHLY PURIFIED COMPOSITIONS OF CELLS ASTELLAS INST FOR REGENERATIVE MEDICINE (US) 2024-12-11 EP claimed
WO-2024081905-A2 FULLY HUMAN MONOCLONAL ANTIBODIES AGAINST HUMAN HER-2 A & G PHARMACEUTICAL, INC. (US) 2024-04-18 WO claimed
US-11779896-B2 Magnetic-optical composite nanostructure KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2023-10-10 US claimed
US-20230310285-A1 DEVELOPER COMPOSITION COMPRISING DIRECT DYE L'OREAL (FR) 2023-10-05 US claimed
WO-2023192788-A1 DEVELOPER COMPOSITION COMPRISING DIRECT DYE L'OREAL (FR) 2023-10-05 WO claimed
WO-2023164581-A2 FULLY HUMAN MONOCLONAL ANTIBODIES AGAINST HUMAN PROGRANULIN A & G PHARMACEUTICAL, INC. (US) 2023-08-31 WO claimed
EP-1292298-A1 INTRACORPOREAL MEDICAMENTS FOR HIGH ENERGY PHOTOTHERAPEUTIC TREATMENT OF DISEASE Photogen, Inc. (US) 2003-03-19 EP claimed
EP-1284727-A1 INTRACORPOREAL MEDICAMENTS FOR PHOTODYNAMIC TREATMENT OF DISEASE Photogen, Inc. (US) 2003-02-26 EP claimed
US-20020161035-A1 Medicaments for chemotherapeutic treatment of disease PHOTOGEN, INC. 2002-10-31 US claimed
EP-1210078-A1 IMPROVED TOPICAL MEDICAMENTS AND METHODS FOR PHOTODYNAMIC TREATMENT OF DISEASE Photogen, Inc. (US) 2002-06-05 EP claimed
WO-2002005812-A1 MEDICAMENTS FOR CHEMOTHERAPEUTIC TREATMENT OF DISEASE PHOTOGEN, INC. (US) 2002-01-24 WO claimed
US-20020001567-A1 Intracorporeal medicaments for high energy phototherapeutic treatment of disease PHOTOGEN, INC. 2002-01-03 US claimed
WO-2001076595-A1 INTRACORPOREAL MEDICAMENTS FOR HIGH ENERGY PHOTOTHERAPEUTIC TREATMENT OF DISEASE PHOTOGEN, INC. (US) 2001-10-18 WO claimed
WO-2001072301-A1 INTRACORPOREAL MEDICAMENTS FOR PHOTODYNAMIC TREATMENT OF DISEASE PHOTOGEN, INC. (US) 2001-10-04 WO claimed
US-20010022970-A1 Intracorporeal medicaments for photodynamic treatment of disease PHOTOGEN, INC. 2001-09-20 US claimed
WO-2001012181-A1 IMPROVED TOPICAL MEDICAMENTS AND METHODS FOR PHOTODYNAMIC TREATMENT OF DISEASE PHOTOGEN, INC. (US) 2001-02-22 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132218-A1 FULLY HUMAN MONOCLONAL ANTIBODIES AGAINST HUMAN HER-2 IGSF11, IGLV6-57, FCGR2A MEN1 3831/4885KMT2A 1769/4885TDP1 2414/4885
US-20230310285-A1 DEVELOPER COMPOSITION COMPRISING DIRECT DYE TYR, CYB5R3, POLR1C MEN1 2132/4885KMT2A 1128/4885TDP1 867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.