Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301652 | 0.75 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL11378113 | 0.70 | — | — | |
| SCHEMBL14257477 | 0.70 | — | — | |
| SCHEMBL2224744 | 0.69 | — | — | |
| SCHEMBL3305715 | 0.67 | ALDH1A1 (0.62) | ALDH1A1 | |
| SCHEMBL10890583 | 0.65 | LMNA (0.48) | ALDH1A1TSHR | |
| SCHEMBL103895 | 0.63 | — | — | |
| SCHEMBL11330491 | 0.63 | — | — | |
| SCHEMBL10528011 | 0.63 | ALDH1A1 (0.37) | ALDH1A1TSHR | |
| SCHEMBL2019340 | 0.62 | TSHR (0.38) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4681295-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| US-7465741-B2 | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BG) | 2008-12-16 | — | — | US | claimed |
| US-7462717-B2 | C6-and C9-substituted chromeno[4,3-c]isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-09 | — | — | US | claimed |
| EP-1532155-B1 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-27 | — | — | EP | claimed |
| EP-1537124-B1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-01 | — | — | EP | claimed |
| US-20060122167-A1 | C6-and c9-substituted isoxazoline derivatives and their use as anti-depressants | JANSSEN-CILAG S.A. (ES) | 2006-06-08 | — | — | US | claimed |
| US-20050256119-A1 | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-11-17 | — | — | US | claimed |
| EP-1537124-A1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-08 | — | — | EP | claimed |
| EP-1532155-A2 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-25 | — | — | EP | claimed |
| WO-2004018482-A2 | C6- AND C9-SUBSTITUTED CHROMENO[4, 3-C]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | claimed |
| WO-2004016621-A1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-26 | — | — | WO | claimed |
| US-7465741-B2 | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BG) | 2008-12-16 | — | — | US | disclosed |
| US-7462717-B2 | C6-and C9-substituted chromeno[4,3-c]isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-09 | — | — | US | disclosed |
| EP-1532155-B1 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2008-02-27 | — | — | EP | disclosed |
| EP-1537124-B1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-01 | — | — | EP | disclosed |
| US-20050256119-A1 | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-11-17 | — | — | US | disclosed |
| EP-1537124-A1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-06-08 | — | — | EP | disclosed |
| EP-1532155-A2 | C6- AND C9-SUBSTITUTED CHROMENO[4,3-c]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004018482-A2 | C6- AND C9-SUBSTITUTED CHROMENO[4, 3-C]ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-03-04 | — | — | WO | disclosed |
| WO-2004016621-A1 | C-SUBSTITUTED TRICYCLIC ISOXAZOLINE DERIVATIVES AND THEIR USE AS ANTI-DEPRESSANTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122167-A1 | C6-and c9-substituted isoxazoline derivatives and their use as anti-depressants | HTR2C, HTR7, DRD4 | ALDH1A1 618/4885TSHR 293/4885 |
| US-20050256119-A1 | C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants | ADRA2C, PARK7, TPH2 | ALDH1A1 1556/4885TSHR 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.