Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SPR | P35270 | 11/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6899970 | 0.84 | LMNA (0.35) | KMT2ALMNAMAPTSPRHTT | |
| SCHEMBL7734302 | 0.80 | LMNA (0.34) | KMT2ALMNAMAPTSPRHTT | |
| SCHEMBL6899995 | 0.79 | LMNA (0.37) | KMT2ALMNAMAPTSPR | |
| SCHEMBL15799985 | 0.75 | RAB9A (0.34) | KMT2ALMNAMAPTHTTNPSR1 | |
| SCHEMBL432792 | 0.74 | KMT2A (0.52) | KMT2ALMNAMAPTSPRHTT | |
| SCHEMBL493850 | 0.72 | MAPT (0.45) | KMT2ALMNAMAPTSPRHTT | |
| SCHEMBL7733528 | 0.72 | KCNA4 (0.37) | — | |
| SCHEMBL435036 | 0.71 | KMT2A (0.44) | KMT2ALMNAMAPTSPRHTT | |
| SCHEMBL435037 | 0.71 | KMT2A (0.44) | KMT2ALMNAMAPTSPRHTT | |
| SCHEMBL16675316 | 0.69 | KMT2A (0.37) | KMT2ALMNAMAPTSPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754207-B2 | Process for the preparation of rapamycin derivatives | CADILA HEALTHCARE LIMITED (IN) | 2014-06-17 | — | — | US | claimed |
| US-20120202988-A1 | PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES | CADILA HEALTHCARE LIMITED (IN) | 2012-08-09 | — | — | US | claimed |
| EP-2480557-A2 | PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES | Cadila Healthcare Limited (IN) | 2012-08-01 | — | — | EP | claimed |
| WO-2011051960-A2 | PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES | CADILA HEALTHCARE LIMITED (IN) | 2011-05-05 | — | — | WO | claimed |
| US-8754207-B2 | Process for the preparation of rapamycin derivatives | CADILA HEALTHCARE LIMITED (IN) | 2014-06-17 | — | — | US | disclosed |
| US-8258299-B2 | Process for preparation of temsirolimus | Chungwa Chemical Synthesis & Biotech Co., Ltd. (TW) | 2012-09-04 | — | — | US | disclosed |
| US-20120202988-A1 | PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES | CADILA HEALTHCARE LIMITED (IN) | 2012-08-09 | — | — | US | disclosed |
| US-20100249415-A1 | Process for preparation of temsirolimus | CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD. (TW) | 2010-09-30 | — | — | US | disclosed |
| US-7202256-B2 | Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779 | WYETH (US) | 2007-04-10 | — | — | US | disclosed |
| US-7202256-B2 | Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779 | WYETH (US) | 2007-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249415-A1 | Process for preparation of temsirolimus | RICTOR, MTOR, MLST8 | KMT2A 1942/4885LMNA 3396/4885MAPT 2047/4885 |
| US-20120202988-A1 | PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES | RICTOR, MTOR, RPTOR | KMT2A 3567/4885LMNA 4108/4885MAPT 3593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.