Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 2/20 | 0.46 |
| ▸ | ADH1C | P00326 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL1515874 | 0.92 | ADH1C (0.44) | ADH1AADH1CALDH1A1ATMFAAH | |
| Carbamic Acid SCHEMBL30426519 | 0.90 | ALDH1A1 (0.43) | ADH1AADH1CALDH1A1ATMFAAH | |
| Oxalic Acid SCHEMBL28457781 | 0.86 | L3MBTL3 (0.41) | ADH1AADH1CALDH1A1ATMFAAH | |
| Methyl Alcohol SCHEMBL2135197 | 0.86 | PHGDH (0.46) | ADH1AADH1CALDH1A1ATMFAAH | |
| Bicarbonate SCHEMBL1580783 | 0.86 | L3MBTL3 (0.43) | ALDH1A1ATML3MBTL3 | |
| SCHEMBL283931 | 0.86 | ADH1A (0.50) | ADH1AADH1CALDH1A1FAAHPHGDH | |
| SCHEMBL1679002 | 0.86 | ADH1A (0.50) | ADH1AADH1CALDH1A1FAAHPHGDH | |
| SCHEMBL20733112 | 0.86 | ADH1A (0.50) | ADH1AADH1CALDH1A1FAAHPHGDH | |
| SCHEMBL28469806 | 0.86 | ADH1A (0.50) | ADH1AADH1CALDH1A1FAAHPHGDH | |
| SCHEMBL13356252 | 0.86 | ADH1A (0.50) | ADH1AADH1CALDH1A1FAAHPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114523600-B | Dissolving and cooling double-kettle circulating type plastic-aluminum separation and recovery device and method | 北京科技大学 | 2023-02-24 | — | — | CN | claimed |
| CN-114523600-A | Dissolving and cooling double-kettle circulating type plastic-aluminum separation and recovery device and method | 北京科技大学 | 2022-05-24 | — | — | CN | claimed |
| CN-114523600-B | Dissolving and cooling double-kettle circulating type plastic-aluminum separation and recovery device and method | 北京科技大学 | 2023-02-24 | — | — | CN | disclosed |
| CN-114523600-B | Dissolving and cooling double-kettle circulating type plastic-aluminum separation and recovery device and method | 北京科技大学 | 2023-02-24 | — | — | CN | disclosed |
| CN-114523600-A | Dissolving and cooling double-kettle circulating type plastic-aluminum separation and recovery device and method | 北京科技大学 | 2022-05-24 | — | — | CN | disclosed |
| EP-2493849-B1 | METHOD OF SEPARATION EMPLOYING SWITCHABLE HYDROPHILICITY SOLVENTS | UNIV KINGSTON (CA) | 2021-12-08 | — | — | EP | disclosed |
| US-10363336-B2 | Methods and systems for treating liquids using switchable solvents | BATTELLE ENERGY ALLIANCE, LLC (US) | 2019-07-30 | — | — | US | disclosed |
| CN-109394994-A | It is a kind of to treat anti-recurrence pharmaceutical composition of condyloma acuminatum and preparation method thereof | 王玺 | 2019-03-01 | — | — | CN | disclosed |
| CN-108862954-A | A method of oily waste is handled using switching mode mixed solvent system | 西南石油大学 | 2018-11-23 | — | — | CN | disclosed |
| US-9399194-B2 | Methods for treating a liquid using draw solutions | BATTELLE ENERGY ALLIANCE, LLC (US) | 2016-07-26 | — | — | US | disclosed |
| CN-102762533-B | Convertible hydrophilic solvent and using method thereof | 金斯顿女王大学 | 2016-06-29 | — | — | CN | disclosed |
| US-20150240051-A1 | SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF | GREENCENTRE CANADA (CA) | 2015-08-27 | — | — | US | disclosed |
| US-8900444-B2 | Switchable hydrophilicity solvents and methods of use thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2014-12-02 | — | — | US | disclosed |
| US-20140235908-A1 | SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF | GREENCENTRE CANADA (CA) | 2014-08-21 | — | — | US | disclosed |
| US-8580124-B2 | Switchable hydrophilicity solvents and methods of use thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2013-11-12 | — | — | US | disclosed |
| WO-2013032742-A1 | METHODS AND SYSTEMS FOR TREATING LIQUIDS USING SWITCHABLE SOLVENTS | BATTELLE ENERGY ALLIANCE, LLC (US) | 2013-03-07 | — | — | WO | disclosed |
| US-20130048561-A1 | METHODS AND SYSTEMS FOR TREATING LIQUIDS USING SWITCHABLE SOLVENTS | BATTELLE ENERGY ALLIANCE, LLC (US) | 2013-02-28 | — | — | US | disclosed |
| EP-2493849-A1 | SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF | Queen's University At Kingston (CA) | 2012-09-05 | — | — | EP | disclosed |
| US-20110257334-A1 | Switchable Hydrophilicity Solvents and Methods of Use Thereof | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2011-10-20 | — | — | US | disclosed |
| WO-2011050469-A1 | SWITCHABLE HYDROPHILICITY SOLVENTS AND METHODS OF USE THEREOF | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2011-05-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257334-A1 | Switchable Hydrophilicity Solvents and Methods of Use Thereof | AQP4, AQP1, AQP3 | ADH1A 925/4885ADH1C 807/4885ALDH1A1 4318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.