Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 10/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439751 | 0.82 | CA2 (0.39) | CYP1A2CYP3A4CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL17194969 | 0.82 | CA2 (0.39) | CYP1A2CYP3A4CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL9258894 | 0.79 | KDM4E (0.50) | CYP1A2ALDH1A1HSD17B10TDP1TSHR | |
| SCHEMBL29904766 | 0.78 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL7011881 | 0.78 | CYP1A2 (0.60) | CYP1A2CYP3A4CYP2C19ALDH1A1HSD17B10 | |
| SCHEMBL1194484 | 0.78 | ALDH1A1 (0.55) | CYP1A2ALDH1A1HSD17B10TDP1TSHR | |
| SCHEMBL30022592 | 0.78 | KDM4E (0.48) | CYP1A2ALDH1A1HSD17B10TDP1TSHR | |
| SCHEMBL30578381 | 0.78 | PTPRC (0.46) | CYP1A2CYP2C19ALDH1A1TDP1TSHR | |
| SCHEMBL17194933 | 0.77 | ALDH1A1 (0.39) | ALDH1A1CA2KDM4ECLK4 | |
| SCHEMBL19229862 | 0.76 | ALDH1A1 (0.39) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242531-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-08-03 | — | — | US | disclosed |
| US-20200102311-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | US | disclosed |
| US-9556190-B2 | Piperidinyloxy lactone orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556190-B2 | Piperidinyloxy lactone orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160318944-A1 | PIPERIDINYLOXY LACTONE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160318944-A1 | PIPERIDINYLOXY LACTONE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242531-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | CYP1A2 767/4885CYP3A4 1831/4885CYP2C19 561/4885 |
| US-20200102311-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | CYP1A2 767/4885CYP3A4 1831/4885CYP2C19 561/4885 |
| US-20160318944-A1 | PIPERIDINYLOXY LACTONE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, CRHR1 | CYP1A2 3121/4885CYP3A4 3823/4885CYP2C19 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.