Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18190715 | 0.81 | ROCK2 (0.46) | ROCK2CSF1RKDRFLT3GSK3A | |
| SCHEMBL18203052 | 0.74 | LMNA (0.44) | TP53LMNABRD4MAPTPGR | |
| SCHEMBL4254017 | 0.73 | KDM4E (0.54) | TP53LMNAMAPT | |
| SCHEMBL13568102 | 0.72 | SLC6A3 (0.53) | ROCK2CSF1RKDRFLT3GSK3A | |
| SCHEMBL4831306 | 0.72 | NR1H4 (0.56) | LMNASLC6A4SLC6A3SLC6A2MAPT | |
| SCHEMBL2084410 | 0.71 | DAO (0.43) | LMNABRD4GABRA1GABRG2GABRB3 | |
| SCHEMBL184016 | 0.71 | SLC6A3 (0.72) | SLC6A4SLC6A3SLC6A2MAPT | |
| SCHEMBL18189458 | 0.70 | GRIA1 (0.54) | ROCK2CSF1RKDRFLT3GSK3A | |
| SCHEMBL21900281 | 0.70 | GRIA1 (0.47) | MAPTCHEK1 | |
| SCHEMBL29996454 | 0.69 | PGR (0.61) | LMNABRD4GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016176449-A1 | BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-11-03 | — | — | WO | disclosed |