Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | QDPR | P09417 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191353 | 0.82 | LMNA (0.55) | EPHX2EPHX1CYP1A2TDP1LMNA | |
| SCHEMBL8947886 | 0.82 | LMNA (0.55) | EPHX2EPHX1CYP1A2TDP1LMNA | |
| SCHEMBL4509387 | 0.82 | LMNA (0.37) | KDM4ESMN1; SMN2LMNAHSD17B10 | |
| Hydrochloric Acid SCHEMBL1835887 | 0.80 | LMNA (0.53) | EPHX2EPHX1CYP1A2TDP1LMNA | |
| SCHEMBL190928 | 0.79 | CYP1A2 (0.48) | EPHX2EPHX1CYP1A2TDP1QDPR | |
| SCHEMBL5707633 | 0.78 | EPHX2 (0.43) | EPHX2EPHX1CYP1A2TDP1QDPR | |
| SCHEMBL18519658 | 0.78 | EPHX2 (0.43) | EPHX2EPHX1CYP1A2TDP1QDPR | |
| SCHEMBL18711893 | 0.77 | CYP1A2 (0.46) | EPHX2EPHX1CYP1A2TDP1QDPR | |
| SCHEMBL12036175 | 0.77 | CYP1A2 (0.46) | EPHX2EPHX1CYP1A2TDP1QDPR | |
| SCHEMBL13621147 | 0.77 | ALDH1A1 (0.47) | CYP1A2TDP1RIPK1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160326108-A1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2016-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326108-A1 | PYRROLIDINYL SULFONE DERIVATIVES AND THEIR USE AS ROR GAMMA MODULATORS | RORC, RORB, RORA | EPHX2 2486/4885EPHX1 2195/4885CYP1A2 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.