Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.45 |
| ▸ | SCD | O00767 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.42 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230321 | 0.92 | ADORA2A (0.48) | TRPV4MAPTADORA3DHODHADORA2A | |
| SCHEMBL18230361 | 0.88 | ADORA3 (0.46) | TRPV4KDM4EMAPTADORA3MEN1 | |
| SCHEMBL18230503 | 0.88 | ADORA2A (0.45) | TRPV4MAPTADORA3MEN1NPC1 | |
| SCHEMBL18230513 | 0.87 | TLR7 (0.49) | KDM4EMAPTSCDDHODHADORA2A | |
| SCHEMBL18230296 | 0.86 | TRPV1 (0.54) | TRPV4KDM4EMAPTMAPK1ADORA3 | |
| SCHEMBL18230411 | 0.85 | ADORA3 (0.61) | TRPV4KDM4EMAPTADORA3SCD | |
| SCHEMBL18230233 | 0.84 | ADORA2A (0.48) | TRPV4KDM4EMAPTADORA3MEN1 | |
| SCHEMBL18230504 | 0.83 | SCD (0.47) | KDM4EMAPTADORA3SCDMEN1 | |
| SCHEMBL18230507 | 0.82 | PCSK9 (0.48) | TRPV4ADORA3SCDMEN1NPC1 | |
| SCHEMBL18230409 | 0.82 | ADORA2A (0.50) | TRPV4MAPTADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |