Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | RHOC | P08134 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18230321 | 0.94 | ADORA2A (0.48) | ADORA3ADORA2AADORA1TRPV4TRPV1 | |
| SCHEMBL18230414 | 0.91 | ADORA2A (0.51) | ADORA3ADORA2AADORA1TRPV4KDM4E | |
| SCHEMBL18230503 | 0.91 | ADORA2A (0.45) | ADORA3ADORA2AADORA1TRPV4TRPV1 | |
| SCHEMBL18230513 | 0.90 | TLR7 (0.49) | ADORA2AADORA1TRPV1TLR7DHODH | |
| SCHEMBL18230296 | 0.88 | TRPV1 (0.54) | ADORA3ADORA2AADORA1TRPV4TRPV1 | |
| SCHEMBL18230282 | 0.88 | TRPV4 (0.56) | ADORA3ADORA2AADORA1TRPV4DHODH | |
| SCHEMBL18230363 | 0.88 | ADORA3 (0.49) | ADORA3ADORA2AADORA1TRPV4ACLY | |
| SCHEMBL18230284 | 0.85 | ADORA2A (0.39) | ADORA3ADORA2AADORA1TRPV4KDM4E | |
| SCHEMBL18230233 | 0.85 | ADORA2A (0.48) | ADORA3ADORA2AADORA1TRPV4TRPV1 | |
| SCHEMBL18230392 | 0.83 | ADORA3 (0.51) | ADORA3ADORA2AADORA1TRPV4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |