Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY2 | P41231 | 9/20 | 0.71 |
| ▸ | P2RY6 | Q15077 | 5/20 | 0.71 |
| ▸ | P2RY4 | P51582 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.64 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.64 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.64 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.64 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.64 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | P2RY14 | Q15391 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cytidine SCHEMBL574822 | 0.96 | LMNA (0.67) | P2RY2P2RY6P2RY4LMNATHRB | |
| Doxecitine SCHEMBL9674279 | 0.92 | P2RY2 (0.61) | P2RY2P2RY6P2RY4LMNATHRB | |
| Cytidine SCHEMBL7196447 | 0.91 | LMNA (0.79) | P2RY2P2RY6P2RY4LMNATHRB | |
| Doxribtimine SCHEMBL29124320 | 0.90 | P2RY2 (0.60) | P2RY2P2RY6P2RY4LMNATHRB | |
| Cytidine SCHEMBL17371752 | 0.90 | LMNA (0.80) | P2RY2P2RY6P2RY4LMNATHRB | |
| Cytidine SCHEMBL600535 | 0.90 | LMNA (0.80) | P2RY2P2RY6P2RY4LMNATHRB | |
| Uridine SCHEMBL2563446 | 0.88 | SLC28A1 (0.78) | P2RY2P2RY6P2RY4LMNASLC28A1 | |
| Cytidine SCHEMBL4468985 | 0.85 | LMNA (0.65) | P2RY2P2RY6P2RY4LMNATHRB | |
| Doxribtimine SCHEMBL6518312 | 0.85 | LMNA (0.62) | P2RY2P2RY6P2RY4LMNATHRB | |
| Doxribtimine SCHEMBL787714 | 0.85 | LMNA (0.62) | P2RY2P2RY6P2RY4LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200297749-A1 | Methods and Pharmaceutical Composition for Modulation Polarization and Activation of Macrophages | UNIVERSITÉ PARIS-SACLAY (FR) | 2020-09-24 | — | — | US | disclosed |
| EP-3685830-A1 | METHODS AND PHARMACEUTICAL COMPOSITION FOR MODULATION POLARIZATION AND ACTIVATION OF MACROPHAGES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) | 2020-07-29 | — | — | EP | disclosed |
| US-20180125876-A1 | Methods and Pharmaceutical Composition for Modulation Polarization and Activation of Macrophages | INST NAT SANTE RECH MED (FR) | 2018-05-10 | — | — | US | disclosed |
| EP-3297615-A1 | METHODS AND PHARMACEUTICAL COMPOSITION FOR MODULATION POLARIZATION AND ACTIVATION OF MACROPHAGES | INSERM - Institut National de la Santé et de la Recherche Médicale (FR) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016185026-A1 | METHODS AND PHARMACEUTICAL COMPOSITION FOR MODULATION POLARIZATION AND ACTIVATION OF MACROPHAGES | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180125876-A1 | Methods and Pharmaceutical Composition for Modulation Polarization and Activation of Macrophages | P2RY2, P2RY1, P2RY12 | P2RY2 1/4885P2RY6 6/4885P2RY4 4/4885 |
| US-20200297749-A1 | Methods and Pharmaceutical Composition for Modulation Polarization and Activation of Macrophages | P2RY2, P2RY1, P2RY12 | P2RY2 1/4885P2RY6 6/4885P2RY4 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.