Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ANPEP | P15144 | 2/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516706 | 0.79 | KDM4E (0.76) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL16538131 | 0.78 | KDM4E (0.60) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL2801217 | 0.77 | KDM4E (0.54) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL5505906 | 0.76 | KDM4E (0.48) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL5506825 | 0.76 | KDM4E (0.48) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL6009887 | 0.76 | KDM4E (0.48) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL5504924 | 0.76 | KDM4E (0.48) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL28834995 | 0.75 | KDM4E (0.52) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL29100048 | 0.74 | KDM4E (0.50) | KDM4EANPEPERAP2SMN1; SMN2HTT | |
| SCHEMBL3154036 | 0.74 | KDM4E (0.68) | KDM4EANPEPERAP2SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162862-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180162862-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-06-14 | — | — | US | disclosed |
| EP-3303338-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | President and Fellows of Harvard College (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016191658-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-12-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162862-A1 | INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES | SI, UGGT1, ALPI | KDM4E 2392/4885ANPEP 819/4885ERAP2 1685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.