Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MGAM | O43451 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | SI | P14410 | 4/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709192 | 0.81 | HSD17B10 (0.50) | MAPTMGAMGAASIMGAM2 | |
| SCHEMBL18265481 | 0.78 | MAPT (0.79) | MAPTMGAMGAASIMGAM2 | |
| SCHEMBL6654614 | 0.78 | TPMT (0.53) | MAPTMGAMGAASIMGAM2 | |
| SCHEMBL8965944 | 0.77 | HTR2A (0.62) | MAPTPTGS2HSD17B10CYP2D6TDP1 | |
| SCHEMBL23580897 | 0.77 | MGAM (0.40) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL1122521 | 0.76 | PTGS2 (0.64) | MAPTPTGS2HSD17B10CYP3A4ALOX15 | |
| SCHEMBL2744248 | 0.75 | TSHR (0.50) | MAPTPTGS2HSD17B10ALOX15TSHR | |
| SCHEMBL8846485 | 0.75 | TRPA1 (0.47) | MGAMGAASIMGAM2KDM4E | |
| SCHEMBL18265491 | 0.74 | TRPA1 (0.71) | MAPTMGAMGAASIMGAM2 | |
| SCHEMBL19632491 | 0.72 | ALOX15 (0.48) | PTGS2HSD17B10ALOX15TSHRHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3097904-B1 | DEPIGMENTING AGENTS TO LIGHTEN THE SKIN | AFFICHEM (FR) | 2019-08-14 | — | — | EP | disclosed |
| WO-2016193220-A1 | SKIN PIGMENTATION MODIFIERS TO DARKEN OR LIGHTEN THE SKIN | AFFICHEM (FR) | 2016-12-08 | — | — | WO | disclosed |
| EP-3097904-A1 | DEPIGMENTING AGENTS TO LIGHTEN THE SKIN | Affichem (FR) | 2016-11-30 | — | — | EP | disclosed |