Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MGAM | O43451 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SI | P14410 | 2/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25364723 | 0.87 | LMNA (0.40) | HSD17B10MGAMGAASIMGAM2 | |
| SCHEMBL9709129 | 0.86 | HSD17B10 (0.50) | HSD17B10MGAMGAASIMGAM2 | |
| SCHEMBL18265474 | 0.81 | MAPT (0.51) | HSD17B10MGAMGAASIMGAM2 | |
| SCHEMBL4877099 | 0.80 | ALDH1A1 (0.56) | GAAALDH1A1CYP2D6LMNAMAPT | |
| SCHEMBL168322 | 0.80 | ALDH1A1 (0.64) | GAAALDH1A1CYP2D6LMNAMAPT | |
| SCHEMBL20970915 | 0.80 | HTR2A (0.66) | HSD17B10TSHRALDH1A1LMNANPSR1 | |
| SCHEMBL8965944 | 0.78 | HTR2A (0.62) | HSD17B10ALOX15TSHRALDH1A1CYP2D6 | |
| SCHEMBL5307529 | 0.78 | HSD17B10 (0.43) | HSD17B10ALDH1A1LMNANPSR1MAPT | |
| SCHEMBL5307526 | 0.78 | HSD17B10 (0.43) | HSD17B10ALDH1A1LMNANPSR1MAPT | |
| SCHEMBL25317242 | 0.77 | ACHE (0.50) | HSD17B10MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471516-A1 | Tricyclic heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-19 | — | — | EP | disclosed |