Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17008212 | 1.00 | CTSK (0.45) | CTSKGPR119SLC6A9 | |
| SCHEMBL18279702 | 0.94 | CTSK (0.52) | CTSKGPR119SLC6A9 | |
| SCHEMBL17008214 | 0.94 | CTSK (0.52) | CTSKGPR119SLC6A9 | |
| SCHEMBL17008292 | 0.91 | CTSK (0.45) | CTSKGPR119 | |
| SCHEMBL17008286 | 0.87 | CTSK (0.45) | CTSKGPR119SLC6A9 | |
| SCHEMBL18892313 | 0.87 | CTSK (0.45) | CTSKGPR119SLC6A9 | |
| SCHEMBL18279699 | 0.86 | CTSK (0.63) | CTSK | |
| SCHEMBL18279804 | 0.86 | CTSK (0.63) | CTSK | |
| SCHEMBL18892468 | 0.86 | CTSK (0.44) | CTSKGPR119SLC6A9 | |
| SCHEMBL17008294 | 0.85 | CTSK (0.51) | CTSKGPR119SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104705-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |
| US-9656990-B2 | Cathepsin cysteine protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160355502-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355502-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | CTSB, CTSS, CTSZ | CTSK 4/4885GPR119 3031/4885SLC6A9 3139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.