Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.48 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15458834 | 0.88 | MAPK8 (0.43) | DRD2TBXA2RMAPK8RNASEH1AR | |
| SCHEMBL15458850 | 0.86 | LMNA (0.48) | RNASEH1LMNAALDH1A1MAPTGAA | |
| SCHEMBL182807 | 0.80 | MAPK8 (0.57) | MAPK8LMNAARALDH1A1MAPT | |
| SCHEMBL3363334 | 0.76 | MAPK8 (0.53) | MAPK8ARALDH1A1MAPTGAA | |
| SCHEMBL15458889 | 0.74 | FEN1 (0.39) | LMNAPLA2G2AALDH1A1GAAPKM | |
| SCHEMBL7886361 | 0.73 | MAPK8 (0.48) | MAPK8LMNAARALDH1A1MAPT | |
| SCHEMBL23760001 | 0.73 | MAPK8 (0.56) | MAPK8PLA2G2AALDH1A1MAPTGAA | |
| SCHEMBL20477211 | 0.71 | ALDH1A1 (0.48) | DRD2TBXA2RMAPK8PLA2G2AALDH1A1 | |
| SCHEMBL9280321 | 0.70 | RNASEH1 (0.48) | DRD2TBXA2RRNASEH1PLA2G2AADCY10 | |
| SCHEMBL22079307 | 0.70 | RNASEH1 (0.57) | RNASEH1ALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921388-B2 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2014-12-30 | — | — | US | disclosed |
| US-8921388-B2 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2014-12-30 | — | — | US | disclosed |
| US-20140038990-A1 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | SAVIRA PHARMACEUTICALS GMBH (AT) | 2014-02-06 | — | — | US | disclosed |
| US-20140038990-A1 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | SAVIRA PHARMACEUTICALS GMBH (AT) | 2014-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038990-A1 | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | DPYD, DHODH, ALAD | DRD2 1822/4885TBXA2R 4371/4885MAPK8 2225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.