Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.33 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18281143 | 0.82 | GABRP (0.40) | RAB9AKDM6BKDM4AKDM4DKDM3B | |
| SCHEMBL23193740 | 0.77 | CYP4F2 (0.49) | ALDH1A1RAB9ANPC1HSP90AB1MAPT | |
| SCHEMBL10064185 | 0.71 | HSP90AB1 (0.50) | ALDH1A1RAB9ANPC1HSP90AB1CYP4F2 | |
| SCHEMBL21702330 | 0.70 | ALDH1A1 (0.55) | ALDH1A1RAB9ANPC1HSP90AB1MAPT | |
| SCHEMBL18281160 | 0.69 | RORC (0.49) | SMN1; SMN2 | |
| SCHEMBL25406145 | 0.68 | HSP90AB1 (0.47) | ALDH1A1RAB9ANPC1HSP90AB1CYP4F2 | |
| SCHEMBL23242638 | 0.68 | RAB9A (0.47) | ALDH1A1RAB9ANPC1HSP90AB1MAPT | |
| SCHEMBL29990038 | 0.68 | RAB9A (0.47) | ALDH1A1RAB9ANPC1HSP90AB1MAPT | |
| SCHEMBL21679073 | 0.68 | ALDH1A1 (0.40) | ALDH1A1RAB9ANPC1HSP90AB1MAPT | |
| SCHEMBL21678965 | 0.68 | GAA (0.39) | ALDH1A1RAB9ANPC1HSP90AB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319942-B1 | ROR-GAMMA MODULATORS | LEAD PHARMA B V (NL) | 2020-03-11 | — | — | EP | disclosed |
| US-20190040012-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING B.V. (NL) | 2019-02-07 | — | — | US | disclosed |
| US-10118895-B2 | ROR gamma (RORγ) modulators | LEAD PHARMA HOLDING B.V. (NL) | 2018-11-06 | — | — | US | disclosed |
| US-20180141909-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING B.V. (NL) | 2018-05-24 | — | — | US | disclosed |
| EP-3319942-A1 | ROR GAMMA (RORY) MODULATORS | Lead Pharma Holding B.V. (NL) | 2018-05-16 | — | — | EP | disclosed |
| WO-2016193468-A1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190040012-A1 | ROR GAMMA (RORY) MODULATORS | RORC, RORA, RORB | ALDH1A1 1160/4885RAB9A 454/4885NPC1 832/4885 |
| US-20180141909-A1 | ROR GAMMA (RORY) MODULATORS | RORC, RORA, RORB | ALDH1A1 1085/4885RAB9A 369/4885NPC1 830/4885 |
| US-10118895-B2 | ROR gamma (RORγ) modulators | RORC, RORA, RORB | ALDH1A1 1059/4885RAB9A 615/4885NPC1 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.