Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 1/20 | 0.40 |
| ▸ | SOD1 | P00441 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16006769 | 0.85 | KARS1 (0.43) | KARS1SOD1FDPSCYP19A1HSP90AA1 | |
| SCHEMBL18290211 | 0.81 | SOD1 (0.53) | KARS1SOD1FDPSMEN1USP2 | |
| SCHEMBL18290223 | 0.68 | SOD1 (0.34) | KARS1SOD1FDPS | |
| SCHEMBL18290357 | 0.66 | FDPS (0.46) | FDPSKDM4EMEN1USP2TP53 | |
| SCHEMBL29934500 | 0.66 | SOD1 (0.52) | KARS1SOD1FDPSCYP19A1HSP90AA1 | |
| SCHEMBL8014515 | 0.64 | RXRA (0.49) | KARS1SOD1TP53CYP3A4MAPT | |
| SCHEMBL18290204 | 0.63 | POLB (0.30) | — | |
| SCHEMBL18290294 | 0.62 | SOD1 (0.43) | KARS1SOD1FDPS | |
| SCHEMBL18290291 | 0.62 | KARS1 (0.47) | KARS1SOD1FDPSCYP19A1HSP90AA1 | |
| SCHEMBL18290302 | 0.61 | SOD1 (0.47) | KARS1SOD1FDPSCYP19A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |