Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.52 |
| ▸ | POLA1 | P09884 | 8/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | SOD1 | P00441 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29507670 | 0.86 | KARS1 (0.56) | KARS1POLA1FDPSCYP3A4USP2 | |
| SCHEMBL29414883 | 0.86 | KARS1 (0.56) | KARS1POLA1FDPSCYP3A4USP2 | |
| 18-Hydroxyferruginol SCHEMBL18290210 | 0.83 | KARS1 (0.67) | KARS1POLA1FDPSSOD1CYP3A4 | |
| 18-Hydroxyferruginol SCHEMBL32666150 | 0.83 | KARS1 (0.67) | KARS1POLA1FDPSSOD1CYP3A4 | |
| SCHEMBL18290295 | 0.83 | FDPS (0.57) | KARS1FDPSCYP3A4USP2MAPT | |
| Hinokiol SCHEMBL18290363 | 0.75 | KARS1 (0.63) | KARS1POLA1FDPS | |
| Hinokiol SCHEMBL854936 | 0.75 | KARS1 (0.63) | KARS1POLA1FDPS | |
| SCHEMBL18290206 | 0.73 | KARS1 (0.66) | KARS1POLA1CYP3A4MAPTALOX15 | |
| Ferruginol SCHEMBL13423521 | 0.72 | KARS1 (0.73) | KARS1POLA1FDPSCYP3A4USP2 | |
| Ferruginol SCHEMBL5315022 | 0.72 | KARS1 (0.73) | KARS1POLA1FDPSCYP3A4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016192631-A1 | ABIETANE-TYPE DITERPENE COMPOUND HAVING LIPID-LOWERING ACTIVITY, METHOD FOR PREPARING SAME, AND USE OF SAME | 中国科学院上海药物研究所 | 2016-12-08 | — | — | WO | disclosed |