SCHEMBL182909

SCHEMBL182909

O=C1[C]=Nc2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
CDC25B P30305 2/20 0.38
MAOA P21397 4/20 0.36
APAF1 O14727 3/20 0.36
TDP2 O95551 2/20 0.36
KDM4E B2RXH2 2/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 2/20 0.36
GALK1 P51570 2/20 0.36
POLB P06746 2/20 0.36
S100A4 P26447 2/20 0.36
MAPK1 P28482 2/20 0.36
RECQL P46063 2/20 0.36
PTPRC P08575 2/20 0.36
CES2 O00748 1/20 0.36
TERT O14746 1/20 0.36
NPC1 O15118 1/20 0.36
PLIN1 O60240 1/20 0.36
S1PR4 O95977 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6646609 0.71 MEN1 (0.38) MEN1KMT2ACDC25BMAOAAPAF1
SCHEMBL3043881 0.71
SCHEMBL7834812 0.68 MAOA (0.37) MEN1KMT2ACDC25BMAOAAPAF1
SCHEMBL10974212 0.64 GSK3B (0.37) MEN1KMT2ACDC25BMAOAAPAF1
SCHEMBL624689 0.63 MEN1 (0.39) MEN1KMT2ACDC25BMAOAAPAF1
SCHEMBL1920482 0.62 NOS3 (0.39) MEN1KMT2AMAOAMAPTNPC1
SCHEMBL2095985 0.62 KMT2A (0.50) MEN1KMT2ACDC25BMAOAAPAF1
SCHEMBL22474210 0.62 HRH4 (0.33) NPC1RAB9ASMN1; SMN2
SCHEMBL7921203 0.62
SCHEMBL1750489 0.62 MEN1 (0.58) MEN1KMT2ACDC25BMAOAAPAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 919 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023036177-A1 THIOPHENE RING COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 中国科学院分子细胞科学卓越创新中心 2023-03-16 WO claimed
EP-3927705-A1 IMIDAZOPYRIDINYL COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE DISORDERS 1st Biotherapeutics, Inc. (KR) 2021-12-29 EP claimed
EP-3927706-A1 IMIDAZOPYRIDINYL COMPOUNDS AND USE THEREOF FOR TREATMENT OF PROLIFERATIVE DISORDERS 1st Biotherapeutics, Inc. (KR) 2021-12-29 EP claimed
US-20210347774-A1 IMIDAZOPYRIDINYL COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE DISORDERS 1ST Biotherapeutics, Inc. 2021-11-11 US claimed
US-20200270246-A1 IMIDAZOPYRIDINYL COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE DISORDERS 1ST Biotherapeutics, Inc. 2020-08-27 US claimed
CN-111315727-A Benzothiazole compounds and methods of using the same for treating neurodegenerative diseases 第一生物治疗股份有限公司 2020-06-19 CN claimed
EP-2049502-B1 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS NOVARTIS AG (CH) 2012-01-04 EP claimed
US-7795271-B2 Substituted pyrimidinones PHARMACIA CORPORATION (US) 2010-09-14 US claimed
EP-1620395-B1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS VERNALIS RES LTD (GB) 2009-12-30 EP claimed
US-20090306108-A1 SUBSTITUTED PYRIMIDINONES PFIZER INC 2009-12-10 US claimed
WO-1997049674-A1 MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1997-12-31 WO claimed
WO-1996027595-A1 HETEROCYCLYCARBOXAMIDES AND OTHER COMPOUNDS FOR THE TREATMENT OF THE CARDIAC ARRHYTHMIAS SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1996-09-12 WO claimed
EP-0719263-A1 HETEROCYCLIC CARBOXAMIDE DERIVATIVES WITH ANTIARRHYTHMIC ACTIVITY SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1996-07-03 EP claimed
EP-0710236-A1 AZALICYCLOOCTANE DERIVATIVES AS ANTI-ARRHYTHMIC AGENTS SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1996-05-08 EP claimed
EP-0700389-A1 ANTI-ARRHYTHMIC N-SUBSTITUTED 3-BENZAZEPINES OR ISOQUINOLINES SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1996-03-13 EP claimed
EP-0700385-A1 NOVEL COMPOUNDS SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1996-03-13 EP claimed
WO-1995007903-A1 HETEROCYCLIC CARBOXAMIDE DERIVATIVES WITH ANTIARRHYTHMIC ACTIVITY SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1995-03-23 WO claimed
WO-1995003301-A1 AZALICYCLOOCTANE DERIVATIVES AS ANTI-ARRHYTHMIC AGENTS SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1995-02-02 WO claimed
WO-1994027971-A1 ANTI-ARRHYTHMIC N-SUBSTITUTED 3-BENZAZEPINES OR ISOQUINOLINES SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1994-12-08 WO claimed
WO-1994027967-A1 NOVEL COMPOUNDS SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) 1994-12-08 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306108-A1 SUBSTITUTED PYRIMIDINONES MAPK1, MAP3K8, MAP3K7 MEN1 3915/4885KMT2A 3940/4885CDC25B 463/4885
US-20200270246-A1 IMIDAZOPYRIDINYL COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE DISORDERS SMN1; SMN2, SNCA, HTT MEN1 3004/4885KMT2A 2106/4885CDC25B 3959/4885
US-20210347774-A1 IMIDAZOPYRIDINYL COMPOUNDS AND USE THEREOF FOR TREATMENT OF NEURODEGENERATIVE DISORDERS SMN1; SMN2, SNCA, HTT MEN1 3004/4885KMT2A 2106/4885CDC25B 3959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.