Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CDC25B | P30305 | 2/20 | 0.58 |
| ▸ | MAOA | P21397 | 4/20 | 0.48 |
| ▸ | APAF1 | O14727 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GALK1 | P51570 | 2/20 | 0.48 |
| ▸ | TDP2 | O95551 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | TERT | O14746 | 1/20 | 0.48 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1386281 | 0.84 | MEN1 (0.46) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| SCHEMBL9709542 | 0.83 | MAOA (0.62) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| SCHEMBL9709023 | 0.83 | MAOA (0.62) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| SCHEMBL24062 | 0.82 | MEN1 (0.37) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| SCHEMBL1749823 | 0.79 | GAA (0.50) | MEN1KMT2ACDC25BMAOAMAPT | |
| SCHEMBL9709207 | 0.79 | TDP2 (0.55) | MEN1KMT2ACDC25BTDP2PTPRC | |
| SCHEMBL7921203 | 0.78 | — | — | |
| SCHEMBL14157422 | 0.77 | PTPRC (0.44) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| SCHEMBL3839654 | 0.75 | MEN1 (0.42) | MEN1KMT2ACDC25BMAOAAPAF1 | |
| Anthraquinone SCHEMBL1901249 | 0.75 | MEN1 (1.00) | MEN1KMT2ACDC25BMAOAAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471516-A1 | Tricyclic heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-19 | — | — | EP | claimed |
| US-9493420-B2 | Quinoline derivatives and uses thereof | PORTLAND STATE UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-8658648-B2 | Modified chloroquines with single ring moiety or fused ring moiety | DESIGNMEDIX, INC. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20130310348-A1 | QUINOLINE DERIVATIVES AND USES THEREOF | STATE UNIVERSITY (US) | 2013-11-21 | — | — | US | disclosed |
| US-8524739-B2 | Quinoline derivatives and uses thereof | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY (US) | 2013-09-03 | — | — | US | disclosed |
| EP-2379505-A1 | MODIFIED CHLOROQUINES WITH SINGLE RING MOIETY OR FUSED RING MOIETY | Designmedix, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20110257160-A1 | QUINOLINE DERIVATIVES AND USES THEREOF | Board of Higher Education on behalf of Portland State University | 2011-10-20 | — | — | US | disclosed |
| US-20110251210-A1 | MODIFIED CHLOROQUINES WITH SINGLE RING MOIETY OR FUSED RING MOIETY | PORTLAND STATE UNIVERSITY (US) | 2011-10-13 | — | — | US | disclosed |
| US-7968539-B2 | reversed chloroquines; to treat chloroquine resistant/sensitive malaria parasites; N'-(7-Chloro-quinolin-4-yl)-N-[3-(10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-N-methyl-propane-1,3-diamine | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF PORTLAND STATE UNIVERSITY (US) | 2011-06-28 | — | — | US | disclosed |
| WO-2010065932-A1 | MODIFIED CHLOROQUINES WITH SINGLE RING MOIETY OR FUSED RING MOIETY | DESIGNMEDIX, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| EP-0471516-A1 | Tricyclic heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-02-19 | — | — | EP | disclosed |
| US-4920103-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1990-04-24 | — | — | US | disclosed |
| US-4820694-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1989-04-11 | — | — | US | disclosed |
| US-4820695-A | GRAMNEGATIVE BACTERIA | ELI LILLY AND COMPANY (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0262903-A2 | New acyl derivatives of 20-modified tylosin and desmycosin compounds | ELI LILLY AND COMPANY (US) | 1988-04-06 | — | — | EP | disclosed |
| EP-0262905-A2 | Modifications of 3-0-demethyl-mycinose in macrocin and lactenocin | ELI LILLY AND COMPANY (US) | 1988-04-06 | — | — | EP | disclosed |
| EP-0262904-A2 | Modifications of mycinose and 3-0-demethylmycinose in tylosintype macrolides | ELI LILLY AND COMPANY (US) | 1988-04-06 | — | — | EP | disclosed |
| US-4629786-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1986-12-16 | — | — | US | disclosed |
| EP-0103465-B1 | 20-AMINO MACROLIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1986-09-10 | — | — | EP | disclosed |
| EP-0103465-A1 | 20-Amino macrolide derivatives | ELI LILLY AND COMPANY (US) | 1984-03-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251210-A1 | MODIFIED CHLOROQUINES WITH SINGLE RING MOIETY OR FUSED RING MOIETY | QARS1, MAVS, QDPR | MEN1 3619/4885KMT2A 1757/4885CDC25B 1095/4885 |
| US-20130310348-A1 | QUINOLINE DERIVATIVES AND USES THEREOF | RECQL, QARS1, QTRT1 | MEN1 4170/4885KMT2A 1127/4885CDC25B 1330/4885 |
| US-20110257160-A1 | QUINOLINE DERIVATIVES AND USES THEREOF | RECQL, QARS1, QTRT1 | MEN1 4170/4885KMT2A 1127/4885CDC25B 1330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.