Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | AR | P10275 | 3/20 | 0.39 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IL1B | P01584 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28009482 | 0.83 | MAPT (0.49) | RAPGEF4ALDH1A1MAPTARNPC1 | |
| SCHEMBL453843 | 0.79 | IL1B (0.43) | ALDH1A1MAPTARNPC1HTT | |
| SCHEMBL16302385 | 0.79 | AR (0.39) | ALDH1A1MAPTARNPC1HTT | |
| SCHEMBL14338947 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTARHTTBACE1 | |
| SCHEMBL849767 | 0.79 | RAB9A (0.48) | ALDH1A1MAPTARNPC1HTT | |
| SCHEMBL1800169 | 0.77 | ALDH1A1 (0.46) | RAPGEF4ALDH1A1MAPTICMTNPC1 | |
| SCHEMBL10779665 | 0.76 | ALDH1A1 (0.54) | ALDH1A1MAPTICMTNPC1HTT | |
| SCHEMBL20714852 | 0.76 | ICMT (0.45) | RAPGEF4ALDH1A1MAPTICMTNPC1 | |
| SCHEMBL28115527 | 0.76 | AR (0.38) | ALDH1A1MAPTARNPC1HTT | |
| SCHEMBL9189930 | 0.75 | IL1B (0.43) | ALDH1A1MAPTARNPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3112347-B1 | NOVEL ANILINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | KISSEI PHARMACEUTICAL (JP) | 2018-10-31 | — | — | EP | disclosed |
| US-9988350-B2 | Aniline derivative, pharmaceutical composition containing same, and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2018-06-05 | — | — | US | disclosed |
| US-20170320821-A1 | NOVEL ANILINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-11-09 | — | — | US | disclosed |
| US-9718771-B2 | Aniline derivative, pharmaceutical composition containing same, and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2017-08-01 | — | — | US | disclosed |
| EP-3112347-A1 | NOVEL ANILINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2017-01-04 | — | — | EP | disclosed |
| US-20160362368-A1 | NOVEL ANILINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2016-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160362368-A1 | NOVEL ANILINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | S1PR1, S1PR3, S1PR2 | RAPGEF4 1189/4885ALDH1A1 2050/4885MAPT 4763/4885 |
| US-20170320821-A1 | NOVEL ANILINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | S1PR3, S1PR1, S1PR2 | RAPGEF4 1337/4885ALDH1A1 2780/4885MAPT 4652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.