Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18308505 | 0.93 | MAPT (0.34) | PDE2AMAPTKDM4EASPHKDM8 | |
| SCHEMBL18308325 | 0.92 | KDM4E (0.35) | PDE2AMAPTKDM4EMETALDH1A1 | |
| SCHEMBL18308537 | 0.91 | MAPT (0.36) | MAPTKDM4EMETPLK1ALDH1A1 | |
| SCHEMBL18308509 | 0.90 | PLK1 (0.38) | MAPTPLK1RAB9ANPC1ALDH1A1 | |
| SCHEMBL18308334 | 0.88 | MAPT (0.33) | MAPT | |
| SCHEMBL18308539 | 0.88 | MET (0.37) | MAPTKDM4EMETALDH1A1LMNA | |
| SCHEMBL18308323 | 0.86 | IDH1 (0.34) | MAPTKDM4EMETALDH1A1LMNA | |
| SCHEMBL18308344 | 0.85 | KIT (0.36) | MAPTKDM4EMETLMNAGAA | |
| SCHEMBL18308331 | 0.85 | RECQL (0.35) | MAPTALDH1A1LMNAGAA | |
| SCHEMBL18308333 | 0.84 | LCK (0.32) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016199943-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-15 | — | — | WO | disclosed |