Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 4/20 | 0.34 |
| ▸ | MET | P08581 | 4/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18308324 | 0.92 | MAPT (0.34) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL18308537 | 0.92 | MAPT (0.36) | IDH1METFYNKITMAPT | |
| SCHEMBL18308344 | 0.91 | KIT (0.36) | IDH1METKITMAPTKDM4E | |
| SCHEMBL18308539 | 0.90 | MET (0.37) | IDH1METFYNMAPTKDM4E | |
| SCHEMBL18308394 | 0.89 | APLNR (0.33) | IDH1METAPLNR | |
| SCHEMBL18308332 | 0.89 | KIT (0.35) | IDH1METKITALDH1A1NPSR1 | |
| SCHEMBL18308329 | 0.88 | PLK1 (0.36) | IDH1METMAPT | |
| SCHEMBL18308342 | 0.86 | PDE2A (0.36) | METMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL18308331 | 0.86 | RECQL (0.35) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL18308325 | 0.86 | KDM4E (0.35) | METMAPTKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016199943-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-15 | — | — | WO | disclosed |