Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 4/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | IDH1 | O75874 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18308539 | 0.95 | MET (0.37) | MAPTKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL18308541 | 0.94 | MET (0.35) | MAPTMETPDGFRBPDGFRAIDH1 | |
| SCHEMBL18308416 | 0.93 | GAA (0.33) | MAPTKDM4EUSP2ALDH1A1LMNA | |
| SCHEMBL18308542 | 0.93 | PLK1 (0.32) | MAPTKDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL18308504 | 0.93 | MET (0.36) | KDM4EMETPDGFRBPDGFRAKIT | |
| SCHEMBL18308344 | 0.92 | KIT (0.36) | MAPTKDM4ELMNAMETPDGFRB | |
| SCHEMBL18308331 | 0.92 | RECQL (0.35) | MAPTALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL18308540 | 0.92 | MRGPRX4 (0.32) | MAPTUSP2TSHRHSD17B10MET | |
| SCHEMBL18308323 | 0.92 | IDH1 (0.34) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL18308511 | 0.90 | MRGPRX4 (0.40) | MAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016199943-A1 | HETEROCYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-12-15 | — | — | WO | disclosed |