Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ESRRA | P11474 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306072 | 0.88 | KMT2A (0.47) | RAB9ASLC2A1KMT2APOLBHDAC6 | |
| Hydrochloric Acid SCHEMBL18306078 | 0.86 | KMT2A (0.49) | RAB9ASLC2A1KMT2APOLBHDAC6 | |
| SCHEMBL14078226 | 0.83 | HTR2C (0.53) | NPC1RAB9AGAAKMT2APOLB | |
| SCHEMBL18313624 | 0.82 | KMT2A (0.57) | KMT2APOLBMEN1 | |
| SCHEMBL18088394 | 0.81 | RAB9A (0.60) | NPC1RAB9AKMT2APOLBHDAC6 | |
| SCHEMBL18313620 | 0.78 | HTR2C (0.46) | RAB9AKMT2APOLBHDAC6PKM | |
| SCHEMBL20496687 | 0.78 | SLC2A1 (0.56) | SLC2A1GAAKMT2APOLBMEN1 | |
| SCHEMBL13792281 | 0.77 | RAB9A (0.56) | NPC1RAB9AKMT2APOLBHDAC6 | |
| SCHEMBL14078225 | 0.77 | RAB9A (0.53) | NPC1RAB9AGAAKMT2APOLB | |
| SCHEMBL24211482 | 0.76 | NPC1 (0.49) | NPC1RAB9AHDAC6ESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11560352-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-01-24 | — | — | US | disclosed |
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-01-14 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-20180265452-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-09-20 | — | — | US | disclosed |
| WO-2016200827-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | ADRM1, SQSTM1, NCOR1 | NPC1 564/4885RAB9A 1676/4885SLC2A1 3177/4885 |
| US-10759739-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | NPC1 562/4885RAB9A 1669/4885SLC2A1 3164/4885 |
| US-11560352-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | NPC1 564/4885RAB9A 1676/4885SLC2A1 3177/4885 |
| US-20180265452-A1 | P62-ZZ CHEMICAL INHIBITOR | SQSTM1, ADRM1, NCOR1 | NPC1 516/4885RAB9A 2190/4885SLC2A1 3720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.