Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18306072 | 0.87 | KMT2A (0.47) | HTR2CHTR2ASLC6A4PPARAKMT2A | |
| Hydrochloric Acid SCHEMBL18306078 | 0.86 | KMT2A (0.49) | HTR2CHTR2ASLC6A4PPARAKMT2A | |
| SCHEMBL18313742 | 0.84 | HTR2C (0.47) | HTR2CHTR2ASLC6A4PPARAKMT2A | |
| SCHEMBL18313621 | 0.84 | KMT2A (0.55) | HTR2CHTR2ASLC6A4KMT2AHTT | |
| SCHEMBL14078226 | 0.81 | HTR2C (0.53) | HTR2CKMT2ARAB9AHTTMEN1 | |
| SCHEMBL17481532 | 0.80 | KMT2A (0.55) | PPARAKMT2ARAB9AHTTMEN1 | |
| SCHEMBL3956974 | 0.79 | HDAC6 (0.58) | HTR2CHTR2ASLC6A4KMT2ARAB9A | |
| SCHEMBL18313460 | 0.78 | NPC1 (0.46) | KMT2ARAB9AHDAC6MEN1PKM | |
| SCHEMBL14078225 | 0.74 | RAB9A (0.53) | HTR2AKMT2ARAB9AHTTMEN1 | |
| SCHEMBL8041968 | 0.73 | SMN1; SMN2 (0.65) | RAB9AHDAC6HDAC3HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11560352-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-01-24 | — | — | US | disclosed |
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-01-14 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| WO-2016200827-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | ADRM1, SQSTM1, NCOR1 | HTR2C 1076/4885HTR2A 894/4885SLC6A4 1327/4885 |
| US-10759739-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | HTR2C 1074/4885HTR2A 886/4885SLC6A4 1304/4885 |
| US-11560352-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | HTR2C 1076/4885HTR2A 894/4885SLC6A4 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.