Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18313571 | 0.87 | ALDH1A1 (0.60) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL18313460 | 0.82 | NPC1 (0.46) | KMT2AMEN1POLB | |
| SCHEMBL31192442 | 0.82 | MEN1 (0.67) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL5864236 | 0.80 | HRH3 (0.72) | SMN1; SMN2ALDH1A1KDM4EHRH3POLB | |
| SCHEMBL11434269 | 0.78 | HRH3 (0.69) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL11684541 | 0.77 | MEN1 (0.74) | KMT2AMEN1ALDH1A1KDM4EHTT | |
| SCHEMBL11684508 | 0.77 | MEN1 (0.74) | KMT2AMEN1ALDH1A1KDM4EHTT | |
| SCHEMBL30147387 | 0.77 | NPC1 (0.40) | KMT2AMEN1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18313621 | 0.77 | KMT2A (0.55) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20847771 | 0.76 | NPC1 (0.65) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11560352-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-01-24 | — | — | US | disclosed |
| US-11560352-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-01-24 | — | — | US | disclosed |
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-01-14 | — | — | US | disclosed |
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-01-14 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-20180265452-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-09-20 | — | — | US | disclosed |
| WO-2016200827-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | ADRM1, SQSTM1, NCOR1 | KMT2A 1181/4885MEN1 3583/4885SMN1; SMN2 3278/4885 |
| US-10759739-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | KMT2A 1183/4885MEN1 3571/4885SMN1; SMN2 3271/4885 |
| US-11560352-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | KMT2A 1181/4885MEN1 3583/4885SMN1; SMN2 3278/4885 |
| US-20180265452-A1 | P62-ZZ CHEMICAL INHIBITOR | SQSTM1, ADRM1, NCOR1 | KMT2A 1076/4885MEN1 3045/4885SMN1; SMN2 3247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.