Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18313571 | 0.87 | ALDH1A1 (0.60) | KMT2AMEN1SMN1; SMN2HTTKDM4E | |
| SCHEMBL18313620 | 0.84 | HTR2C (0.46) | KMT2AMEN1SMN1; SMN2HTTHTR2A | |
| SCHEMBL18313743 | 0.83 | ALDH1A1 (0.50) | KMT2AHTTKDM4EGAAALDH1A1 | |
| SCHEMBL22877395 | 0.79 | HTT (0.43) | KMT2AHTTKDM4EGAAALDH1A1 | |
| SCHEMBL24079779 | 0.78 | BCHE (0.59) | KMT2AMEN1SMN1; SMN2HTTKDM4E | |
| SCHEMBL18313624 | 0.77 | KMT2A (0.57) | KMT2AMEN1SMN1; SMN2HTTKDM4E | |
| SCHEMBL17481532 | 0.75 | KMT2A (0.55) | KMT2AMEN1SMN1; SMN2HTTKDM4E | |
| SCHEMBL18677377 | 0.73 | CCR3 (0.59) | ALDH1A1KCNH2CYP2D6GRIN2BHRH3 | |
| SCHEMBL12204109 | 0.73 | OPRL1 (0.50) | SMN1; SMN2KDM4EALDH1A1HTR2AHTR2C | |
| Carbamic Acid SCHEMBL5490727 | 0.73 | KMT2A (0.53) | KMT2AMEN1SMN1; SMN2HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11560352-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-01-24 | — | — | US | disclosed |
| US-11560352-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-01-24 | — | — | US | disclosed |
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-01-14 | — | — | US | disclosed |
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-01-14 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-20180265452-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-09-20 | — | — | US | disclosed |
| WO-2016200827-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | ADRM1, SQSTM1, NCOR1 | KMT2A 1181/4885MEN1 3583/4885SMN1; SMN2 3278/4885 |
| US-10759739-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | KMT2A 1183/4885MEN1 3571/4885SMN1; SMN2 3271/4885 |
| US-11560352-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | KMT2A 1181/4885MEN1 3583/4885SMN1; SMN2 3278/4885 |
| US-20180265452-A1 | P62-ZZ CHEMICAL INHIBITOR | SQSTM1, ADRM1, NCOR1 | KMT2A 1076/4885MEN1 3045/4885SMN1; SMN2 3247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.