Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.47 |
| ▸ | HTR2A | P28223 | 9/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18313620 | 0.84 | HTR2C (0.46) | HTR2CHTR2ASLC6A4HDAC6HDAC3 | |
| SCHEMBL18313743 | 0.83 | ALDH1A1 (0.50) | HTR2CHTR2ASLC6A4MAOBBACE1 | |
| SCHEMBL3956974 | 0.81 | HDAC6 (0.58) | HTR2CHTR2ASLC6A4HDAC6HDAC3 | |
| SCHEMBL17481533 | 0.79 | KMT2A (0.48) | MAOBGSK3BBACE1PPARARAB9A | |
| SCHEMBL20314097 | 0.76 | SMN1; SMN2 (0.44) | HTR2CHTR2ASLC6A4MAOBGSK3B | |
| SCHEMBL22877395 | 0.76 | HTT (0.43) | HTR2CHTR2ASLC6A4MAOBGSK3B | |
| SCHEMBL17481418 | 0.76 | IDO1 (0.44) | MAOBGSK3BBACE1PPARASMN1; SMN2 | |
| SCHEMBL8041968 | 0.72 | SMN1; SMN2 (0.65) | HDAC6HDAC3HDAC1HDAC8RAB9A | |
| SCHEMBL18306072 | 0.70 | KMT2A (0.47) | HTR2CHTR2ASLC6A4HDAC6PPARA | |
| SCHEMBL13602920 | 0.69 | MAPK14 (0.45) | PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11560352-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-01-24 | — | — | US | disclosed |
| US-11560352-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-01-24 | — | — | US | disclosed |
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-01-14 | — | — | US | disclosed |
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-01-14 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-10759739-B2 | P62-ZZ small molecule modulators | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2020-09-01 | — | — | US | disclosed |
| US-20180265452-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-09-20 | — | — | US | disclosed |
| WO-2016200827-A1 | P62-ZZ CHEMICAL INHIBITOR | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009506-A1 | P62-ZZ SMALL MOLECULE MODULATORS | ADRM1, SQSTM1, NCOR1 | HTR2C 1076/4885HTR2A 894/4885SLC6A4 1327/4885 |
| US-10759739-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | HTR2C 1074/4885HTR2A 886/4885SLC6A4 1304/4885 |
| US-11560352-B2 | P62-ZZ small molecule modulators | ADRM1, SQSTM1, NCOR1 | HTR2C 1076/4885HTR2A 894/4885SLC6A4 1327/4885 |
| US-20180265452-A1 | P62-ZZ CHEMICAL INHIBITOR | SQSTM1, ADRM1, NCOR1 | HTR2C 1074/4885HTR2A 1167/4885SLC6A4 1471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.