Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9704603 | 0.79 | OPRK1 (0.42) | LMNAOPRK1PDE3ACHRM2ADRA2A | |
| SCHEMBL5222768 | 0.68 | OPRK1 (0.39) | LMNAOPRK1PDE3ACHRM2ADRA2A | |
| Iodide SCHEMBL11461823 | 0.68 | CHEK1 (0.37) | LMNAOPRK1PDE3ACHRM2ADRA2A | |
| SCHEMBL18319671 | 0.65 | LMNA (0.41) | LMNAOPRK1PDE4DGAATSPO | |
| SCHEMBL11471916 | 0.65 | MEN1 (0.35) | LMNAOPRK1PDE3AMEN1KMT2A | |
| SCHEMBL23892731 | 0.63 | AADAT (0.42) | LMNAOPRK1PDE3ACHRM2ADRA2A | |
| SCHEMBL30600563 | 0.63 | OPRK1 (0.44) | LMNAOPRK1PDE3ACHRM2ADRA2A | |
| SCHEMBL28701831 | 0.63 | OPRK1 (0.44) | LMNAOPRK1PDE3ACHRM2ADRA2A | |
| SCHEMBL28470317 | 0.62 | KMT2A (0.41) | LMNAOPRK1CHRM2ADRA2APDE4D | |
| SCHEMBL11361155 | 0.62 | CHEK1 (0.43) | KDRMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10702537-B2 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2020-07-07 | — | — | US | disclosed |
| US-10561668-B1 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY (US) | 2020-02-18 | — | — | US | disclosed |
| US-20190224211-A1 | DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE | 2019-07-25 | — | — | US | disclosed |
| US-10022383-B2 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2018-07-17 | — | — | US | disclosed |
| US-20160367565-A1 | DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10022383-B2 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | TSPO, SLC18A2, SLC18A3 | LMNA 4218/4885OPRK1 9/4885PDE3A 3218/4885 |
| US-10561668-B1 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | TSPO, SLC18A2, SLC18A3 | LMNA 4218/4885OPRK1 9/4885PDE3A 3218/4885 |
| US-20160367565-A1 | DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION | TSPO, SLC18A2, SLC18A3 | LMNA 4218/4885OPRK1 9/4885PDE3A 3218/4885 |
| US-10702537-B2 | Devices and methods of treating methamphetamine addiction and medical and behavioral consequences of methamphetamine use and of HIV infection | TSPO, SLC18A2, SLC18A3 | LMNA 4218/4885OPRK1 9/4885PDE3A 3218/4885 |
| US-20190224211-A1 | DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION | TSPO, SLC18A2, SLC18A3 | LMNA 4218/4885OPRK1 9/4885PDE3A 3218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.