Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18322866 | 0.90 | PDGFRB (0.47) | HRH3SRCKCNH2PDGFRBPDGFRA | |
| SCHEMBL18322938 | 0.87 | CHRNB1 (0.43) | HRH3KCNH2DYRK1APDGFRBPDGFRA | |
| SCHEMBL18322902 | 0.85 | PDGFRB (0.47) | HRH3KCNH2PDGFRBPDGFRAMAP4K1 | |
| SCHEMBL18322946 | 0.84 | HTR7 (0.37) | HRH3KCNH2HTR2AHTR7ACHE | |
| SCHEMBL18322916 | 0.82 | GSK3B (0.45) | WNT1CLK2CLK3GSK3BDYRK1A | |
| SCHEMBL18318522 | 0.80 | PIK3CD (0.45) | — | |
| SCHEMBL18318438 | 0.79 | LMNA (0.44) | HRH3SRCKCNH2 | |
| SCHEMBL18322886 | 0.79 | TGFBR1 (0.44) | HRH3HTR2AACHE | |
| SCHEMBL18322904 | 0.79 | GSK3B (0.42) | HRH3KCNH2GSK3B | |
| SCHEMBL18322981 | 0.79 | ROCK1 (0.43) | HRH3WNT1CLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |