Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15339562 | 0.78 | ALDH1A1 (0.38) | MAOBKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL15342931 | 0.75 | PKM (0.50) | GAAMAPTSMN1; SMN2CTSSCTSK | |
| SCHEMBL23426122 | 0.74 | SAE1 (0.41) | MAPTSMN1; SMN2PDE1BMAPK1PDE2A | |
| SCHEMBL18329684 | 0.73 | NPC1 (0.44) | GAAMAPTSMN1; SMN2KDM4EPDE2A | |
| SCHEMBL23426162 | 0.70 | LTA4H (0.40) | CTSSCTSKPDE1BKDM4EALDH1A1 | |
| SCHEMBL15328543 | 0.69 | DGAT1 (0.41) | UCHL1 | |
| SCHEMBL19355326 | 0.68 | NPBWR1 (0.42) | CTSSCTSKPDE1BPDE4BGABRG2 | |
| SCHEMBL14027882 | 0.68 | MAOB (0.58) | GAAMAOBMAPTSMN1; SMN2PDE1B | |
| SCHEMBL29600977 | 0.68 | MAOB (0.58) | GAAMAOBMAPTSMN1; SMN2PDE1B | |
| SCHEMBL18056104 | 0.68 | PDE1B (0.51) | PDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10442791-B2 | DNA-PK inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-10-15 | — | — | US | disclosed |
| US-20180208579-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED | 2018-07-26 | — | — | US | disclosed |
| US-9878993-B2 | DNA-PK inhibitors for treatment of cancer | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-01-30 | — | — | US | disclosed |
| US-20160368899-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368899-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | GAA 234/4885MAOB 2973/4885OPRK1 1307/4885 |
| US-10442791-B2 | DNA-PK inhibitors | POLK, DTYMK, DCK | GAA 234/4885MAOB 2973/4885OPRK1 1307/4885 |
| US-20180208579-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | GAA 234/4885MAOB 2973/4885OPRK1 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.