Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18332392 | 0.92 | NOD2 (0.44) | NOD2NOD1ALOX5PTGDR2KMT2A | |
| SCHEMBL18331685 | 0.88 | NOD2 (0.44) | NOD2NOD1ALOX5PTGDR2KMT2A | |
| SCHEMBL18331687 | 0.86 | NOD2 (0.45) | NOD2NOD1ALOX5LMNATSHR | |
| SCHEMBL18332388 | 0.84 | MMP13 (0.43) | NOD2NOD1ALOX5KMT2AMEN1 | |
| SCHEMBL20584087 | 0.84 | PTGDR2 (0.38) | NOD2NOD1ALOX5PTGDR2KMT2A | |
| SCHEMBL18332169 | 0.80 | ALOX5 (0.38) | NOD2NOD1ALOX5PTGDR2KMT2A | |
| SCHEMBL18332167 | 0.79 | HRH3 (0.47) | NOD2NOD1ALOX5PTGDR2ALDH1A1 | |
| SCHEMBL18332165 | 0.77 | NOD2 (0.44) | NOD2NOD1ALOX5PTGDR2ALDH1A1 | |
| SCHEMBL18332391 | 0.76 | PTGDR2 (0.39) | NOD2NOD1ALOX5PTGDR2MAPT | |
| SCHEMBL18331914 | 0.76 | NOD1 (0.53) | NOD2NOD1ALOX5KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| US-10479780-B2 | Aminopyrazole derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2019-11-19 | — | — | US | disclosed |
| US-20180362509-A1 | AMINOPYRAZOLE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2018-12-20 | — | — | US | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016204261-A1 | AMINOPYRAZOLE DERIVATIVES | 中外製薬株式会社 | 2016-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479780-B2 | Aminopyrazole derivatives | SRC, GRK2, GRK3 | NOD2 2986/4885NOD1 2710/4885ALOX5 3139/4885 |
| US-20180362509-A1 | AMINOPYRAZOLE DERIVATIVES | SRC, GRK2, GRK3 | NOD2 2986/4885NOD1 2710/4885ALOX5 3139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.